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NONMYELOABLATIVE PERIPHERAL BLOOD PROGENITOR TRANSPLANTATION FOR REFRACTORY LEUKEMIA
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- Author:
- No author available
- Journal Title:
- JOURNAL OF LEUKEMIA & LYMPHOMA
- Issue:
- 3
- DOI:
- 10.3760/cma.j.issn.1009-9921.2004.03.003
- Key Word:
- 造血干细胞移植;异基因;非清髓;白血病;慢粒
Abstract： 目的:观察非清髓造血干细胞移植对慢粒慢性期(CML-CP)、慢粒加速期(CML-AP)的疗效.方法:用福达华(F)30mg/m2×6 d,白消安(B)4mg·kg-1·d-1×2 d,环磷酰胺(CTS)600mg/d×2 d,±Ara-C对7例HLA全相合者进行预处理,并对其造血恢复等指标动态观察.结果:7例患者造血顺利恢复,ANC>05×109/L平均为13 d,BPC>20×109/L平均为11d.+30天时经短串重复系列(STR-PCR)检测,7例植活患者中4例为完全嵌合状态(CDC),3例为混合嵌合体.+90天时又有1例患者转为CDC.中位随访6(1-13)个月,7例患者均无病生存.结论:非清髓性造血干细胞移植是慢粒慢性期、加速期的有效治疗手段,对于年龄较大患者亦有良好耐受性.
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