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ASSOCIATION OF HLA-ALLELES WITH ACUTE LYMPHOBLASTIC LEUKEMIA
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- Author:
- No author available
- Journal Title:
- JOURNAL OF LEUKEMIA & LYMPHOMA
- Issue:
- 1
- DOI:
- 10.3760/cma.j.issn.1009-9921.2004.01.004
- Key Word:
- 急性淋巴细胞白血病(ALL);HLA基因;基因频率
Abstract： 目的:探讨HLA基因与成人急性淋巴细胞白血病(ALL)发病之间的关联.方法:采用序列特异性引物聚合酶链反应(PCR-SSP)DNA分型技术,对105例成人急性淋巴细胞白血病患者和142名正常对照进行HLA基因分型,分析HLA基因分布频率在2组中的差异.结果:ALL组与正常对照组相比,A*0201(35.71%)和B*4801(5.71%)基因频率明显增高(RR=2.340 7、7.5134,x2=9.57 8、9.538 8 P＜0.005),DRB1*0701基因频率(9.52%)显著低于正常组(RR=0.439 2,x2=6.990 2P＜0.01).结论:HLA-B*4801和DRB1*0701基因可分别被认为是ALL白血病发病的危险标志和保护标志.
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