You Position: Home > Paper
PHENYLBUTYRATE INHIBIT PROLIFERATION IN KASUMI-1 CELLS
( views:200, downloads:12 )
- Author:
- No author available
- Journal Title:
- JOURNAL OF LEUKEMIA & LYMPHOMA
- Issue:
- 1
- DOI:
- 10.3760/cma.j.issn.1009-9921.2004.01.003
- Key Word:
- 白血病;脱乙酰化酶;生长抑制
Abstract： 目的:探讨组蛋白脱乙酰化酶抑制剂苯丁酸钠(PB)体外对Kasumi-1细胞的生长抑制作用.方法:应用MTT比色法、锥虫蓝拒染法和集落细胞培养连续传代方法观察PB对细胞的生长抑制作用和自我更新能力的影响.结果:PB呈剂量依赖性抑制Kasumi-1细胞的生长,半数抑制浓度(IC.)约为2.3 mmol/L.结论:脱乙酰化酶抑制剂苯丁酸钠抑制Kasum-1细胞的生长.
- [1]H, Asou,S, Tashiro,K, Hamamoto,etc.Establishment of a human acute myeloid leukemia cell line (Kasumi-1) with 8; 21 chromosome translocation.[J].1991,77.
- [2]Marks PA,Rifkind RA,Richon VM.Histone deacetylase inhibitors: inducers of differentiation or apoptosis of transformed cells.[J].2000,92(15).