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The Effects of BU3-CY Conditioning Regimen in RI-BMT
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- Author:
- No author available
- Journal Title:
- JOURNAL OF LEUKEMIA & LYMPHOMA
- Issue:
- 4
- DOI:
- 10.3760/cma.j.issn.1009-9921.2003.04.004
- Key Word:
- BU3-CY;方案预处理;异基因骨髓移植
Abstract： 目的:探索BU3-CY预处理方案在减低预处理剂量骨髓移植(RI-BMT)中的作用.方法:以BU3-CY减低预处理剂量的方法对7例白血病患者作RI-HSCT,供者均为亲兄第姐妹(rela-tive sibling donor,RSD),其中有3例为HLA 5/6位点相合者,输入G-CSF动员的供者单个核细胞(MNC)4×108/kg～8×108/kg,以MTX,CsA,MMF预防GVHD.结果:7例患者均成功植入,WBC上升到1×109/L为+11天(10天～15天),Plt上升到20×109/L为+12天(9天～17天),除口腔炎外,无明显的毒副作用.移植后(11天～45天)均有经DNA检测证实的完全供者嵌合(FDC),例1于+20天时为混合嵌合,+45天时为完全嵌合.急性GVHD3例, 度GVHD,+62天时死亡,2例为Ⅰ度GVHD治愈,3例有慢性GVHD,2例为广泛性,1例为局限性.6/7例无病存活6个月(2个月～12个月).结论:BU3-CY的预处理方案可作为减低顸处理剂量骨髓移植(RI-BMT或RI-HSCT)的预处理方法.
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