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EVALUATING RESPONSES TO THE TREATMENT OF INTERMEDIATE AND HIGH-GRADE NON-HODGKIN'S LYMPHOMAS BY CHOP-BASED REGIMEN USING INTERNATIONAL PROGNOSTIC INDEX
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- Author:
- No author available
- Journal Title:
- JOURNAL OF LEUKEMIA & LYMPHOMA
- Issue:
- 6
- DOI:
- 10.3760/cma.j.issn.1009-9921.2001.06.008
- Key Word:
- 非霍奇金淋巴瘤;国际预后指标;化疗;疗效
Abstract： 目的:进一步提高对CHOP为主方案治疗中高度恶性非霍奇金淋巴瘤(NHL)疗效的认识.方法:用国际预后指数(IPI)对31例以CHOP为主方案治疗的中高度恶性NHL患者的疗效进行评价.根据IPI将患者分为低危和高危两大组,比较两组患者的生存状况.结果:低危和高危组完全缓解患者分别为16/21例(76%)和3/10例(30%),部分缓解分别为3/21例(14%)和4/10例(40%),复发/进展分别为2/21例(10%)和3/10例(30%).中位生存期分别为84(3～132)月和6.5(0.75～52)月,两组差异显著(P=0.0032).1.5年总生存率(OS)分别为75.89%和20%,低危组5年OS为59.15%,10年OS为33.83%.结论:CHOP为主的第一代化疗方案对于不同危险程度的进展性NHL患者疗效明显不同.CHOP对于低危患者仍可作为首选和标准方案,对于高危患者可以考虑更强的或实验性的化疗方案.
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