Abstract： At present,several clinical practice guidelines for osteoarthritis have been developed.Although contradictions about some recommendations are still in dispute,large number of clinical practice guidelines recommended core treatments,namely education,weight loss and exercise therapy.Thus,the diagnosis and treatment of primary osteoarthritis should focus on the above three treatments.However,we have to develop the clinical practice guidelines for osteoarthritis in primary hospital,based on the characteristics of osteoarthritis in China,the burden of disease,the health literacy of patients and the clinical decision-making of diagnosis and treatment of primary osteoarthritis in primary medical care.We suggest to formulate guidelines for the diagnosis and treatment of osteoarthritis in primary medical care to regulate primary interventions.