Abstract： Objective To investigate the clinical predictors of cytomegalovirus (CMV) infection after liver transplantation.Methods The clinical data of 182 patients(146 male and 36 female with a mean age of (50 ± 7)years) receiving liver transplantation in Beijing Chaoyang Hospital between January 2004 and December 2008 were retrospectively analyzed.All patients were divided into two groups,namely the CMV infection group(n =24) and the control group (n =158).Logistic regression was used to identify the predictive factors of postoperative CMV infection.Results According to univariate analysis results,the factors for CMV infection were acute liver failure (P =0.032),MELD score ≥ 30 (P =0.001),liver retransplantation(P =0.002),acute rejection (P =0.000) and delayed graft function (P =0.022).According to multi-analysis results,MELD score ≥ 30 (P =0.037,95％ CI:1.194-271.461) and acute rejection(P =0.033,95％ CI:1.179-51.863) were proved to be independent predictors by multivariate analysis.Conclusion The study indicates that MELD score ≥ 30 and acute rejection are the independent predictors of CMV infection.