Abstract： Objectives To investigate the expression of P120catenin in pancreatic carcinoma and to explore the association between P120catenin gene polymorphism at T755G position and pancreatic carcinoma.Methods The expression of P120catenin in 52 cases of pancreatic carcinoma and normal pancreatic tissues on the mRNA and protein levels were evaluated by RT-PCR and Western Blot methods respectively.P120catenin gene polymorphism at 1755G position of in 52 patients and 60 healthy controls were examined by PCR-restriction fragment length polymorphism (PCR-RFLP) technique.Results The mRNA and protein expressions of P120catenin in pancreatic carcinoma tissues were significantly lower than normal pancreatic tissues (P=0.000,P=0.002).Reduced expression of P120catenin mRNA was significantly correlated with differentiated (P=0.033),lymph node metastasis (P=0.004),vascular invasion (P=0.022),and pTNM stage (P=0.003).Additionally,there were significant difference of P120catenin gene polymorphism genotypes and alleles at T755G position between patients and healthy controls(P=0.008,P=0.016).The GG genotype of P120catenin gene was associated with higher risk of incidence for pancreatic carcinoma compared with the TT genotype (OR=2.765,95% CI=1.312-3.958).Conclusions The reduced expressions of both P120 catenin mRNA and protein in pancreatic carcinoma suggest its association with pancreatic carcinoma development.Polymorphism of P120catenin gene at T755G situation might be a risk factor for pancreatic carcinoma,and it may be used to diagnosis and prevent pancreatic carcinoma early.