Abstract： Objective To analyze the long-term results of Tips,TIPS with coronary vein occlusion (CVO) and combined TIPS and portal azygous disconnection for the treatment of portal hypertension and variceal bleedings. Methods Three hundreds and fifty-eight patients with portal hypertension were admitted because of variceal bleeding from July 1993 to May 2008. All patients were divided into 3 groups :227 cases in group TIPS,36 cases in TIPS and CVO group,95 cases in combined TIPS and portal azygous disconnection group. The rates of successful operation, shunt patency, rebleeding, encephalopathy and survival were observed and compared by statistics methods. Results There were 349 cases (97.5% ) underwent successful surgery and 9 cases with failure surgery. The rates of occluded shunts, encephalopathy, rebleeding,and death in early periods were 2.5%, 31.8% ,4.7% and 9.0% respectively. The rate of encephalopathy and death in group with TIps were higher than in group with combined TIPS and portal azygous disconnection(P<0.01 ). The rate of encephalopathy and death were 41.2% and 24.7% in 85 cases with emergency TIps. During the follow-up 1-15 years, the rate of patency shunts in 12 and 24 months after operation was 74.0% and 48.1% respectively. The rate of 1-year patency shunts in group with combined TIPS and portal azygous disconnection was higher than in group with TIPS, TIPS and CVO ( P < 0.01 and P<0.05 ). The rebleeding in group with TIPS was higher than in group with combined TIPS and portal azygous disconnection (P<0.01 ) ,and the survival rate in group with TIPS was lower than in group with TIPS and CVO, combined TIps and portal azygous disconnection (P<0.01 and P<0.01) . Conclusions TIPS is an efficient therapy for portal hypertension with CVO, combined TIPS and portal azygous disconnection can improve the results of TIPS for portal hypertension.