Abstract： Objective To investigate the outcomes in patients with pregnancy complicated with intracranial tumors who underwent comprehensive management.Methods We retrospectively reviewed the clinical data,anesthesia management and outcome of pregnant women complicated with intracranial tumor admitted to Beijing Tiantan Hospital,Capital Medical University from December 2012 to December 2017 and 19 cases were enrolled into this study.One case was at the first trimester (≤ 12 weeks),9 at the second trimester (13-28 weeks) and 9 at the third trimester (＞ 28 weeks).The operation,anesthesia and newborn management for pregnancy with brain tumor is a multidisciplinary teamwork of neurology,neurosurgery,obstetrics and anesthesiology for both mothers and newborns.Twelve cases underwent neurosurgical treatment,among which 6 cases underwent cesarean section followed by brain tumor resection or ventriculostomy (1 case).Among those 6 cases,2 underwent surgical treatment at the first stage and 4 underwent surgical treatment 5 to 16 days later.Three benign cases carried on pregnancy after tumor resection.Pregnancy was terminated after tumor resection in 3 cases.A total of 7 cases were conservatively treated,among which 3 had the pituitary tumor and were observed till the cesarean section surgery at full term.The other 4 cases with relatively high surgical risks underwent conservative treatment following cesarean section.Results There were no anesthetic complications in this series.There were 2 cases of intracranial infection,2 cases of electrolyte disorder,1 case of hydrocephalus and 1 case of pneumonia.There was 1 case of in-hospital death in pregnant women.Postoperative follow-up lasted for 8-23 months,with an average of 13.3 ± 3.5 months.There were 3 deaths during the follow-up period.All those 4 cases were patients without resection of tumor.The rest of the patients were in stable condition.There were a total of 16 newborns who were 25-40 weeks of gestation at childbirth.The Apgar scores at birth were 2-10 points,with an average of 8.8 ± 2.2 points.Of those,15 had good clinical outcomes and 1 died 1 months after birth (28 weeks gestation week).Conclusion Individualized perioperative multidisciplinary management for pregnant women complicated with brain tumor might be the optimal approach to secure postoperative outcome of patients and newborns.