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Ⅰ型糖尿病大鼠动物模型建立及周围神经病变指标的观察
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- Author:
- No author available
- Journal Title:
- Chinese Journal of Neurosurgery
- Issue:
- 3
- DOI:
- 10.3760/cma.j.issn.1001-2346.2014.03.029
- Key Word:
- No keyword available
Abstract： 糖尿病性周围神经病(diabetic peripheral neuropathy,DPN)是糖尿病(diabetes mellitus,DM)最为常见的慢性并发症,严重影响患者生活质量.为了研究DPN的发病机制、发病特点及探索新的治疗途径,建立理想的DPN动物实验模型是非常必要的,理想的DPN动物模型可提供类似人类DPN的信息[1].本研究采用腹腔注射小剂量链脲佐菌素(streptozotocin,STZ)的方法制备Ⅰ型DM大鼠模型,观察从DM发病到出现DPN的过程,进而筛选出客观、可靠的神经病变指标,以用于DPN的进一步实验研究.
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