Abstract： Objective To study the effect of p-phenylenediamine(PPD) on liver and kidney function in occupational exposed workers.Methods Workers in a hair dye production enterprise which used pphenylenediamine as a raw material for production were selected as the main research population.Then we conducted a questionnaire survey on the basic conditions of workers and conducted occupational health checkups on general health status,liver and kidney function.Occupational health examination assessment results were tested in Taizhou Cancer Hospital.All data was built using EpiData 3.1 software,and statistical analysis was performed using software SPSS 20.0.Results The liver function indicators including direct bilirubin,prealbumin,total protein,and white protein,globulin,aspartate aminotransferase,glutamyl transpeptidase,and total bilirubin in the workers exposed to high concentration of PPD were at high normal values,and these indicators were significantly different from low PPD concentration group (P＜0.05).The serum creatinine and serum uric acid in the renal function index were significantly higher in workers exposed to PPD than in workers exposed to low concentrations and in the control group (P＜0.05).Conclusion Occupational exposed to PPD may have a hazard to the workers' liver and kidney function.Long-term occupational exposure to PPD may lead to increased cumulative exposure of workers,which may cause potential chronic liver and kidney damage in occupationally exposed populations.