Abstract： Objective To establish the method for determination of titanium dioxide in the air of workplace by inductivehy coupled plasma optical emission spectrometry (ICP-OES). Methods The titanium dioxide was collected by filter membrane and then digested by microwave digestion apparatus in the mixed solvents (HNO3:HF:H2O=4:1:1), dilutedto 25 ml and detected by ICP-OES. Results The sampling efficiency was higher than 95%;the linearity of ICP-OES was good at the range of 10-500μg/ml, the minimum quantitation concentration was 0.72 mg/m3(as collecting 150 L air sample), the maximum quantitation concentration was 21.7 mg/m3(as collecting 960 L air sample), the recovery was ranged from 99.0%-102.0%, the RSD of intra- and inter- batch precision were 0.5%-3.2%and 1.7%-3.5%, respectively. Conclusion The sampling method and determination method meet the requirements of guide for establishing occupational health standards-part 4:determinatin methods of air chemicals in workplace(GBZ/T 210.4-2008), and areapplys to the collection and determination of TiO2 in the air of workplace.