Abstract： Objective To investigate the combination of drugs in blood perfusion-based rescue therapy of acute poisoning thinners.Methods Our department were retrospectively analyzed in May 2011 to October 2014,54 cases thinners poisoning patients choose the thinner should be 44 cases of acute poisoning patients were divided into two groups.Toluene,xylenc group 8 cases;Halogenated hydrocarbon group 34cases;Give blood perfusion 3 to 7 times,compared before and after the blood perfusion of toxicant concentratiou,results and biochemical indicators.Results By selection of 44 patients with acute thinners poisoning in 42 patients were successfully treated,the cure rate was 96％.And treatment in patients with successful both in toluene,xylene,or halogenated hydrocarbon group after blood perfusion its toxicant concentratiou significantly decreased;42patients blood perfusion treatment of the indexes of liver function after than before treatment significantly improved.Conclusion The early hemoperfusion is a very effective way of acute poisoning thinners currently rescue.