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The unbalance of anti-oxidation enzyme system and lipid peroxidation in acute high altitude sickness
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- Author:
- No author available
- Issue:
- 2
- DOI:
- 10.3760/cma.j.issn.1001-9391.2004.02.018
- Key Word:
- 高海拔;脂质过氧化作用
Abstract： 目的探讨抗氧化酶系统失调与脂质过氧化在急性高原反应中的意义.方法从同一生活和工作环境中选取123名男性武警战士作为调查对象,根据是否发生急性高原反应,将其分成病例组和对照组,其中病例组43人,对照组80人.采用南京建成生物研究所提供的试剂盒,检测武警战士血浆中一氧化氮(NO)、一氧化氮合酶(NOS)、活性氧(ROS)、丙二醛(MDA)、谷胱甘肽(GSH)、谷胱甘肽过氧化物酶(GSH-Px)、谷胱甘肽S-转移酶(GSH-ST)、超氧化物歧化酶(SOD)的含量或活力.结果病例组武警战士血浆中GSH、GSH-Px、GSH-ST含量或活力明显低于对照组,差异有显著性(P＜0.01),而病例组的脂质过氧化产物(MDA)水平则明显高于对照组,差异有显著性(P＜0.05).结论急性高原反应武警战士血浆中GSH、GSH-Px、GSH-ST含量或活力低下,以及氧化与抗氧化系统失衡,可能是导致急性高原反应的机制之一.
- [1]T H, Risby,L, Jiang,S, Stoll,etc.Breath ethane as a marker of reactive oxygen species during manipulation of diet and oxygen tension in rats.[J].1999,86.
- [2]Basnyat B,Murdoch DR.High-altitude illness.[J].2003,361(9373).
- [3]主编陈瑗, 周玫.自由基医学基础与病理生理[M].2002.
- [4]Helmy MH,Ramadan MI,El-Bassiouni EA,etc.Changes in the defense against free radicals in the liver and plasma of the dog during hypoxia and/or halothane anaesthesia.[J].1998,128(1).
- [5]Matthew C, Schmidt,E W, Askew,Donald E, Roberts,etc.Oxidative stress in humans training in a cold, moderate altitude environment and their response to a phytochemical antioxidant supplement.[J].2002,13(2).
- [6]S W, Chang,T J, Stelzner,J V, Weil,etc.Hypoxia increases plasma glutathione disulfide in rats.[J].1989,167.
- [7]赵克然,杨毅军,曹道俊(医学).氧自由基与临床[M].1900.