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Application of metagenomic next generation sequencing for pathogen detection in respiratory infectious diseases

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Author:: No author available

Journal Title:: Chinese Journal of Clinical Infectious Diseases

Issue:: 6

DOI:: 10.3760/cma.j.issn.1674-2397.2020.06.016

Key Word:: 高通量测序;宏基因组二代测序;呼吸系统感染;应用;High-throughput sequencing;Metagenomic next generation sequencing;Respiratory infectious diseases;Application

Abstract： Metagenomic next generation sequencing (mNGS) is a non-preference, highly sensitive and highly specific molecular biological detection method. Currently, it is widely used in the auxiliary diagnosis of a variety of infectious diseases in clinical practice, which has greatly improved the survival rate and cure rate of patients. In recent years, there are increasing numbers of reports on the clinical application of mNGS. This article mainly reviews the advantages and challenges in the application of mNGS for diagnosis and treatment of respiratory infectious diseases.

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