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Research on non-culture-based method in diagnosis of invasive candidiasis

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Journal Title:
Chinese Journal of Clinical Infectious Diseases
Key Word:
念珠菌病,侵袭性;非培养法;诊断;Candidiasis, invasive;Non-culture method;Diagnosis

Abstract´╝Ü Invasive candidiasis (IC) is lack of specific clinical symptoms and signs. Conventional microbiological culture for IC diagnosis presents poor sensitivity and time-consuming. Non-culture-based methods include the detection of candida carbohydrates (1, 3-β-D-glucan, mannan/anti-mannan), candida protein and candida nucleic (PCR, T2Candida). Because they are sensitive and less time-consumming, the method have been widely used for IC diagnosis. This article describes the clinical application and limitations of these non-culture methods in the diagnosis of candida diseases, to provide reference for the clinical use.

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