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Research progress on Akkermansia muciniphila in human intestine

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Author:: No author available

Journal Title:: Chinese Journal of Clinical Infectious Diseases

Issue:: 5

DOI:: 10.3760/cma.j.issn.1674-2397.2019.05.013

Key Word:: Akkermansia muciniphila;肠道菌群;代谢性疾病;感染性疾病;Akkermansia muciniphila;Intestinal microbiota;Metabolic disease;infectious disease

Abstract： Recent studies heve demonstrated that Akkermansia muciniphila (A.muciniphila) plays an important role in human health and disease , including regulating the development of the immune system and the metabolic phenotype of the host.This article reviews the research progress on A.muciniphila in recent years, focusing on the basic characteristics , the influencing factors of colonization , and the underlying mechanism of maintaining intestinal homeostasis of A.muciniphila.Additionally, the article summarizes the potential association between A.muciniphila and the chronic metabolic diseases such as obesity , atherosclerosis,diabetes mellitus and infectious diseases.The perspect of A.muciniphila as a new generation of probiotics in clinical medicine and the challenge for its industrialization are also discussed in the article .

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