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Expert consensus on screening for cryptococcal infection among AIDS patients in Zhejiang

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Author:: No author available

Journal Title:: Chinese Journal of Clinical Infectious Diseases

Issue:: 2

DOI:: 10.3760/cma.j.issn.1674-2397.2019.02.001

Key Word:: 隐球菌病;获得性免疫缺陷综合征;筛查;治疗;共识;Cryptococcosis;Acquired immunodeficiency syndrome;Screening;Treatment;Consensus

Abstract： Cryptococcal infection is one of the most common causes of AIDS-related death.Early screening and early anti-cryptococcal treatment can significantly reduce the mortality of AIDS patients.This expert consensus recommends : 1.Patients with CD4 +T lymphocyte ＜200／μL should be screened for cryptococcal antigen ; 2.Lateral-flow assay should be the first choice for screening cryptococcus infection in AIDS patients; 3.HIV patients with positive serum cryptococcal antigen ( CrAg) in screening should be tested for CrAg in cerebrospinal fluid ( CSF); 4.The quantitative detection of CrAg can be carried out if feasible; 5.AIDS patients with asymptomatic cryptococcal antigenemia should receive preemptive fluconazole anticryptococcal therapy ; 6.AIDS patients with positive serum CrAg , and positive CSF CrAg , cryptococcal septicemia, pulmonary cryptococcal disease or cryptococcal disease in other parts should receive standardized therapy according to the relevant anti-cryptococcal guidelines.

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