Paper - WANFANG MED ONLINE

You Position: Home > Paper

Role of Kupffer cells in hepatitis B virus infection

( views:116, downloads:44 )

Author:: No author available

Journal Title:: Chinese Journal of Clinical Infectious Diseases

Issue:: 6

DOI:: 10.3760/cma.j.issn.1674-2397.2017.06.015

Key Word:: 枯否细胞;肝炎病毒,乙型;感染;免疫;Kupffer cells;Hepatitis B virus;Infection;Immunity

Abstract： Hepatitis B virus(HBV)infection is the main cause of chronic liver diseases in China. The clearance of HBV is important for patients with chronic hepatitis B.Current antiviral therapy includes interferon and nucleotide analogues.The adverse reactions of interferon are common which restrict its application.Nucleotide analogues need long-term maintenance treatment.Kupffer cells (KCs) are the main innate immune cells in the liver.Studies have shown that KCs play an important role in hepatitis B virus infection.It can inhibit virus replication effectively , but may also result in immune dysfunction , causing HBV persistence.Understanding the mechanism related to the role of KCs in hepatitis B virus infection may lead to a new approach of antiviral therapy.

Reference

[1].Ron receptor-dependent gene regulation of Kupffer cells during endotoxemia[J].2014,(3).
[2]Hosel M,Quasdorff M,Wiegmann.Not interferon, but interleukin-6 controls early gene expression in hepatitis B virus infection.[J].2009,50(6).
[3]Zhu, C.,Sun, Y.,Luo, X.,etc.Novel mfgl2 Antisense Plasmid Inhibits Murine fgl2 Expression and Ameliorates Murine Hepatitis Virus Type 3-Induced Fulminant Hepatitis in BALB/cJ Mice[J].2006,17(6).
[4]Ludger Leifeld,Christian Trautwein,Franz Ludwig Dumoulin,etc.Enhanced Expression of CD80 (B7-1), CD86 (B7-2), and CD40 and Their Ligands CD28 and CD154 in Fulminant Hepatic Failure[J].1999,154(6).
[5].Pathogenic mechanisms in HBV- and HCV-associated hepatocellular carcinoma[J].2013,13(2).
[6]Delyth M, Reid,Maria, Montoya,Philip R, Taylor,etc.Expression of the beta-glucan receptor, Dectin-1, on murine leukocytes in situ correlates with its function in pathogen recognition and reveals potential roles in leukocyte interactions.[J].2004,76.
[7]Lingxiang, Kong,Yongjie, Zhou,Hong, Bu,etc.Deletion of interleukin-6 in monocytes/macrophages suppresses the initiation of hepatocellular carcinoma in mice.[J].2016.
[8]Gerken G,Schlaak J,Kempf P,etc.Human Kupffer cells secrete IL-10 in response to lipopolysaccharide (LPS) challenge.[J].1995,22(2).
[9]Craig N Jenne,Paul Kubes.Immune surveillance by the liver[J].2013,14(10).
[10]Xin Yu,Peixiang Lan,Xuben Hou,etc.HBV inhibits LPS-induced NLRP3 inflammasome activation and IL-1β production via suppressing the NF-κB pathway and ROS production[J].2017,66(4).
[11]Annette Erhardt,Markus Biburger,Thomas Papadopoulos,etc.IL-10, regulatory T cells, and Kupffer cells mediate tolerance in concanavalin A-induced liver injury in mice[J].2007,45(2).
[12]Li,H.,Zheng,H.-W.,Chen,H.,etc.Hepatitis B virus particles preferably induce Kupffer cells to produce TGF-β1 over pro-inflammatory cytokines[J].2012,44(4).
[13]Mita, Atsuyoshi,Hashikura, Yasuhiko,Tagawa, Yoh-Ichi,etc.Expression of Fas Ligand by Hepatic Macrophages in Patients with Fulminant Hepatic Failure.[J].2005,100(11).
[14]Bertoletti,A.,Ferrari,C..Innate and adaptive immune responses in chronic hepatitis B virus infections:Towards restoration of immune control of viral infection[J].2013,89(TN.1051).
[15]Yin, Wenwei,Lian, Zhexiong,Zheng, Xiaodong,etc.Kupffer Cells Support Hepatitis B Virus-Mediated CD8(+) T Cell Exhaustion via Hepatitis B Core Antigen-TLR2 Interactions in Mice[J].2015,195(7).
[16]A M, Chinnaiyan,K, O'Rourke,M, Tewari,etc.FADD, a novel death domain-containing protein, interacts with the death domain of Fas and initiates apoptosis.[J].1995,81(4).
[17]Wynn TA,Barron L.Macrophages: master regulators of inflammation and fibrosis.[J].2010,30(3).
[18].Crosstalk between innate and adaptive immunity inhepatitis B virus infection[J].2015,0(30).
[19]Mehde M,Kobold D,Knittel T,etc.Expression patterns of matrix metalloproteinases and their inhibitors in parenchymal and non-parenchymal cells of rat liver: regulation by TNF-alpha and TGF-beta1.[J].1999,30(1).
[20]Xiaofeng Liang,Shengli Bi,Weizhong Yang,etc.Reprint of: Epidemiological serosurvey of Hepatitis B in China-Declining HBV prevalence due to Hepatitis B vaccination[J].2013,31.
[21]Xu,L.,Yin,W.,Sun,R.,etc.Kupffer cell-derived IL-10 plays a key role in maintaining humoral immune tolerance in hepatitis B virus-persistent mice[J].2014,59(2).
[22]Jun Wu,Mengji Lu,Zhongji Meng,etc.Toll-like receptor-mediated control of HBV replication by nonparenchymal liver cells in mice[J].2007,46(6).
[23]Boltjes, Arjan,van Montfoort, Nadine,Biesta, Paula J.,etc.Kupffer Cells Interact With Hepatitis B Surface Antigen In Vivo and In Vitro, Leading to Proinflammatory Cytokine Production and Natural Killer Cell Function[J].2015,211(8).
[24]Murray PJ,Wynn TA.Protective and pathogenic functions of macrophage subsets.[J].2011,11(11).
[25].Development of Polymer Modified Electrochemical Sensor for the Determination of Alizarin Carmine in the Presence of Tartrazine[J].2020,32(11).
[26]Sun Y,Xin S,Xu D,etc.Imbalanced intrahepatic cytokine expression of interferon-gamma, tumor necrosis factor-alpha, and interleukin-10 in patients with acute-on-chronic liver failure associated with hepatitis B virus infection.[J].2009,43(2).
[27]Honjo T,Okazaki T.The PD-1-PD-L pathway in immunological tolerance.[J].2006,27(4).
[28]A K Raney,D R Milich,A J Easton,etc.Differentiation-specific transcriptional regulation of the hepatitis B virus large surface antigen gene in human hepatoma cell lines.[J].1990,64(5).
[29]Tian, Yongjun,Kuo, Cheng-fu,Akbari, Omid,etc.Maternal-Derived Hepatitis B Virus e Antigen Alters Macrophage Function in Offspring to Drive Viral Persistence after Vertical Transmission[J].2016,44(5).
[30]Imaizumi T,Matsumiya T,Mori F,etc.Listeria monocytogenes induces the expression of retinoic acid-inducible gene-I.[J].2006,50(10).
[31]Furuichi Y,Isogawa M,Robek MD,etc.Toll-like receptor signaling inhibits hepatitis B virus replication in vivo[J].2005,79(11).
[32]Levy,GA,Liu,M,Ding,J,etc.Molecular and functional analysis of the human prothrombinase gene (HFGL2) and its role in viral hepatitis.[J].2000,156(4).
[33]Bozorgzadeh A,Orloff MS,Crispe IN,etc.TLR-dependent cross talk between human Kupffer cells and NK cells.[J].2008,205(1).
[34]Corbi AL,Aragoneses-Fenoll L,Bustos M,etc.The pathogen receptor liver and lymph node sinusoidal endotelial cell C-type lectin is expressed in human Kupffer cells and regulated by PU.1.[J].2009,49(1).
[35]F V, Chisari,M, Isogawa,S F, Wieland.Pathogenesis of hepatitis B virus infection.[J].2010,58(4).
[36]Catherine Isabell, Real,Mengji, Lu,Jia, Liu,etc.Hepatitis B virus genome replication triggers toll-like receptor 3-dependent interferon responses in the absence of hepatitis B surface antigen.[J].2016.
[37]Qian T,Streetz K,Lemasters JJ,etc.The mitochondrial permeability transition is required for tumor necrosis factor alpha-mediated apoptosis and cytochrome c release.[J].1998,18(11).
[38]Sowa JP,Meng Z,Schlaak JF,etc.Hepatitis B virus suppresses toll-like receptor-mediated innate immune responses in murine parenchymal and nonparenchymal liver cells.[J].2009,49(4).
[39]Crispe IN.The liver as a lymphoid organ.[J].2009,27.
[40]Xianming Yu,Janet E. Mertz.Distinct Modes of Regulation of Transcription of Hepatitis B Virus by the Nuclear Receptors HNF4α and COUP-TF1[J].2003,77(4).
[41]Maier H,Freeman GJ,Isogawa M,etc.PD-1:PD-L1 Interactions Contribute to the Functional Suppression of Virus-Specific CD8+ T Lymphocytes in the Liver.[J].2007,178(5).