You Position: Home > Paper
Clinical effect of sequential therapy with micafungin and reduced-dose voriconazole in prevention of invasive fungal disease after allogeneic hematopoietic stem cell transplantation
( views:245, downloads:186 )
- Author:
- No author available
- Journal Title:
- Chinese Journal of Clinical Infectious Diseases
- Issue:
- 4
- DOI:
- 10.3760/cma.j.issn.1674-2397.2017.04.007
- Key Word:
- 造血干细胞移植;免疫球蛋白同种异型;米卡芬净;伏立康唑;真菌感染;Hematopoietic stem cell transplantation;Immunoglobulin allotypes;Micafungin;Voriconazole;Fungal infection
Abstract： 侵袭性真菌感染(IFI)是异基因造血干细胞移植(Allo-HSCT)患者术后常见感染并发症,也是导致患者死亡的主要原因之一.在Allo-HSCT受者中IFI的发生率为10％ ～25％[1],发生IFI的患者病死率高达60％[2],而且治疗费用高昂,增加患者经济压力[3].由于IFI的临床表现缺乏特异性,真菌培养阳性率低,其早期诊断和治疗比较困难.选择有效的抗真菌治疗药物预防真菌感染成为保证移植成功的重要策略之一.近年来我们采用米卡芬净序贯减量伏立康唑预防Allo-HSCT所致的真菌感染,取得了较好的疗效.
- [1]中国侵袭性真菌感染工作组.血液病/恶性肿瘤患者侵袭性真菌病的诊断标准与治疗原则（第四次修订版）[J].2013,(8).
- [2]Joseph JM,Danziger LH,Jain R.Micafungin: a new echinocandin antifungal.[J].2007,27(1).
- [3]Arlo, Upton,Katharine A, Kirby,Paul, Carpenter,etc.Invasive aspergillosis following hematopoietic cell transplantation: outcomes and prognostic factors associated with mortality.[J].2007,44(4).
- [4]Satoshi Hashino,Lena Morita,Mutsumi Takahata,etc.Administration of micafungin as prophylactic antifungal therapy in patients undergoing allogeneic stem cell transplantation[J].2008,87(1).
- [5]van Burik, Jo-Anne H.,Ratanatharathorn, Voravit,Stepan, Daniel E.,etc.Micafungin versus Fluconazole for Prophylaxis against Invasive Fungal Infections during Neutropenia in Patients Undergoing Hematopoietic Stem Cell Transplantation.[J].2004,39(10).
- [6]Michael Koldehoff,Johames L. Zakrzewski.Modern management of respiratory failure due to pulmonary mycoses following allogeneic hematopoietic stem-cell transplantation[J].2005,79(2).
- [7]Garcia-Vidal C,Marr KA,Kirby KA,etc.Epidemiology of invasive mold infections in allogeneic stem cell transplant recipients: biological risk factors for infection according to time after transplantation.[J].2008,47(8).
- [8]Bow, E. J..Invasive Fungal Infection in Haematopoietic Stem Cell Transplant Recipients: Epidemiology from the Transplant Physician's Viewpoint[J].2009,168(6).
- [9]Urabe A,Yoshida M,Tamura K.Efficacy and safety of micafungin, an echinocandin antifungal agent, on invasive fungal infections in patients with hematological disorders.[J].2009,50(1).