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Clinical effect of sequential therapy with micafungin and reduced-dose voriconazole in prevention of invasive fungal disease after allogeneic hematopoietic stem cell transplantation

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Author:
No author available
Journal Title:
Chinese Journal of Clinical Infectious Diseases
Issue:
4
DOI:
10.3760/cma.j.issn.1674-2397.2017.04.007
Key Word:
造血干细胞移植;免疫球蛋白同种异型;米卡芬净;伏立康唑;真菌感染;Hematopoietic stem cell transplantation;Immunoglobulin allotypes;Micafungin;Voriconazole;Fungal infection

Abstract´╝Ü 侵袭性真菌感染(IFI)是异基因造血干细胞移植(Allo-HSCT)患者术后常见感染并发症,也是导致患者死亡的主要原因之一.在Allo-HSCT受者中IFI的发生率为10% ~25%[1],发生IFI的患者病死率高达60%[2],而且治疗费用高昂,增加患者经济压力[3].由于IFI的临床表现缺乏特异性,真菌培养阳性率低,其早期诊断和治疗比较困难.选择有效的抗真菌治疗药物预防真菌感染成为保证移植成功的重要策略之一.近年来我们采用米卡芬净序贯减量伏立康唑预防Allo-HSCT所致的真菌感染,取得了较好的疗效.

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