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Expression of Gli1 gene in liver tissues from patients with hepatitis B-related hepatocellular carcinoma and its clinical significance
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- Author:
- No author available
- Journal Title:
- Chinese Journal of Clinical Infectious Diseases
- Issue:
- 3
- DOI:
- 10.3760/cma.j.issn.1674-2397.2012.03.012
- Key Word:
- 肝炎,乙型;肝细胞癌;转录因子Gli1;Hepatitis B;Hepatocellular carcinoma;Transcription factor Gli1
Abstract： 在胚胎发育、组织分化过程中,调控细胞分化与增殖的信号通路,如Hedgehog( HH)在肿瘤的发生发展中起着重要作用[1],而其同源基因SonicHedgehog (SHH)在哺乳动物中作用最为广泛.研究显示,SHH信号通路中的转录因子Gli1功能异常可阻碍细胞增殖和分化,影响组织器官发育,提示Gli1可能与各种类型癌症的发生相关[2-4].在肝脏的发育和疾病过程中,SHH信号通路参与肝脏母细胞的分化以及成熟肝脏损伤后的肝细胞再生过程[5].当HBV损伤肝细胞后,SHH信号通路将激活肝细胞的修复与再生,如果转录因子Gli1功能异常,最终可能导致肿瘤的发生.本研究检测了乙型肝炎相关性肝细胞癌组织中Gli1基因的表达情况,并与癌旁肝组织的表达情况比较,探讨其与乙型肝炎相关性肝细胞癌的临床病理特征的关系,为乙型肝炎相关性肝细胞癌的临床诊断、治疗及预后提供依据.
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