You Position: Home > Paper
Potential antiviral resistance mutations to adefovir dipivoxil therapy in patients with chronic hepatitis B
( views:292, downloads:108 )
- Author:
- No author available
- Journal Title:
- Chinese Journal of Clinical Infectious Diseases
- Issue:
- 6
- DOI:
- 10.3760/cma.j.issn.1674-2397.2011.06.010
- Key Word:
- 肝炎病毒,乙型;抗药性;突变;基因;阿德福韦酯;Hepatitis B virus;Drug resistance;Mutation;Gene;Adefovir dipivoxil
Abstract： HBV耐药变异的产生是很难避免的,加强对HBV变异特征的研究,更好地了解变异在耐药发生及疾病预后中的作用,从而采取有针对性的防治措施具有重要意义.本研究对未经阿德福韦酯(ADV)治疗的患者进行了ADV主要耐药相关变异位点的检测,并对其临床特点进行分析.
- [1]中华医学会肝病学分会,中华医学会感染病学分会.慢性乙型肝炎防治指南（2010年版）[J].2011,(1).
- [2]郑南红,纪礽斌,周文红,等.乙型肝炎病毒基因YMDD自然变异的检测及意义[J].2007,(3).
- [3]李新艳,尹有宽,张继明,等.阿德福韦耐药乙型肝炎病毒毒株生物学特性的研究[J].2009,(8).
- [4]Lok AS,Keeffe EB,Marrero JA,etc.Adefovir-resistant hepatitis B can be associated with viral rebound and hepatic decompensation.[J].2005,43(6).
- [5]Xu Z,Liu Y,Xu T,etc.Acute hepatitis B infection associated with drug-resistant hepatitis B virus.[J].2010,48(4).
- [6]Chu CK,Yadav V.Molecular mechanisms of adefovir sensitivity and resistance in HBV polymerase mutants: a molecular dynamics study.[J].2004,14(16).
- [7]Frider B,Rivero CW,Castillo AI,etc.Naturally occurring hepatitis B virus (HBV) variants with primary resistance to antiviral therapy and S-mutants with potential primary resistance to adefovir in Argentina.[J].2010,87(1).
- [8]Esteban-Mur R,Koff RS,Gane EJ,etc.Report of an international workshop: Roadmap for management of patients receiving oral therapy for chronic hepatitis B.[J].2007,5(8).