You Position: Home > Paper
The challenge for precision treatment of obstructive sleep apnea
( views:108, downloads:99 )
- Author:
- No author available
- Journal Title:
- Chinese Journal of Tuberculosis and Respiratory Diseases
- Issue:
- 10
- DOI:
- 10.3760/cma.j.cn112147-20210409-00237
- Key Word:
- No keyword available
Abstract： 阻塞性睡眠呼吸暂停（OSA）主要表现为睡眠中反复发生上气道塌陷，目前衡量病情严重程度的指标是呼吸暂停低通气指数和夜间血氧饱和度。但是，不同的致病因素使得OSA的临床表现、病理生理学机制、预后等存在异质性，仅以上述两个指标不能够完全表达OSA的病情；目前OSA的主要治疗方法——持续气道正压通气、口腔矫治器、手术，也不能覆盖所有的OSA患者。因此，OSA呼唤精准治疗，而精准治疗的前提是明确OSA亚型，目前缺乏大的亚型数据库成为精准治疗面临的最大挑战，本文将就此进行探讨。
- [1]中华医学会呼吸病学分会睡眠呼吸障碍学组.阻塞性睡眠呼吸暂停低通气综合征诊治指南（2011年修订版）[J].2012,(1).
- [2]Eckert,D.J.,White,D.P.,Jordan,A.S.,etc.Defining phenotypic causes of obstructive sleep apnea: Identification of novel therapeutic targets[J].2013,188(8).
- [3]Newman, Anne B.,Foster, Greg,Givelber, Rachel,etc.Progression and Regression of Sleep-Disordered Breathing With Changes in Weight: The Sleep Heart Health Study.[J].2005,165(20).
- [4]Weiwei Quan,Danni Zheng,R. Douglas McEvoy,etc.High Risk Characteristics for Recurrent Cardiovascular Events among Patients with Obstructive Sleep Apnoea in the SAVE Study[J].2018,2–3.
- [5]Li, Wen-Yang,Gakwaya, Simon,Saey, Didier,etc.Assessment of tongue mechanical properties using different contraction tasks[J].2017,123(1).
- [6]Zinchuk, Andrey,Yaggi, Henry K..Phenotypic Subtypes of OSA A Challenge and Opportunity for Precision Medicine[J].2020,157(2).
- [7]Zinchuk, Andrey V.,Jeon, Sangchoon,Koo, Brian B.,etc.Polysomnographic phenotypes and their cardiovascular implications in obstructive sleep apnoea[J].2018,73(5).
- [8]George D. Vavougios,George Natsios,Chaido Pastaka,etc.Phenotypes of comorbidity in OSAS patients: combining categorical principal component analysis with cluster analysis[J].2016,25(1).