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半乳甘露聚糖试验诊断侵袭性曲霉病假阳性原因研究进展

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Author:: No author available

Journal Title:: Chinese Journal of Tuberculosis and Respiratory Diseases

Issue:: 10

DOI:: 10.3760/cma.j.cn112147-20191216-00832

Key Word:: No keyword available

Abstract：半乳甘露聚糖（GM）是曲霉细胞壁的一种多聚糖，GM试验的主要检测物质即为GM抗原。在血清或支气管肺泡灌洗液中检测GM含量，可应用于侵袭性曲霉病（IA）的辅助诊断和疗效评估。我国目前在临床中已较为广泛地开展GM试验检测，但由于GM试验假阳性率较高，对IA的诊断和疗效评估的准确性造成一定影响，从而导致误诊及抗真菌药物应用不规范。引起GM试验假阳性的原因较多，本文将通过合并用药、宿主基础疾病和其他原因分别阐述，旨在帮助临床医生正确评估GM试验的检测结果，指导临床实践。

Reference

[1]林鹏程,赖茜茜,周颖,等.半乳甘露聚糖试验对非粒细胞缺乏患者侵袭性肺曲霉病的诊断价值[J].2016,(12).
[2]杨启文,倪语星,林丽开,等.临床微生物实验室真菌检测能力建设基本要求专家共识[J].2019,(7).
[3]于书娴,崔学范,马婷,等.G试验和GM试验对侵袭性真菌病诊断价值的Meta分析[J].2016,(2).
[4]中华医学会呼吸病学分会感染学组,中华结核和呼吸杂志编辑委员会.肺真菌病诊断和治疗专家共识[J].2007,(11).
[5].Molecular and nonmolecular diagnostic methods for invasive fungal infections[J].2014,27(3).
[6]Jones O,Cleveland KO,Gelfand MS.A case of disseminated histoplasmosis following autologous stem cell transplantation for Hodgkin's lymphoma: an initial misdiagnosis with a false-positive serum galactomannan assay.[J].2009,11(3).
[7]Wheat LJ,Walsh TJ.Diagnosis of invasive aspergillosis by galactomannan antigenemia detection using an enzyme immunoassay.[J].2008,27(4).
[8]Izutsu K,Oshima K,Asai T,etc.False-positive Aspergillus galactomannan antigenaemia after haematopoietic stem cell transplantation.[J].2008,61(2).
[9]Bottero J,Aubry A,Porcher R,etc.Occurrence and kinetics of false-positive Aspergillus galactomannan test results following treatment with beta-lactam antibiotics in patients with hematological disorders.[J].2006,44(2).
[10]Aceti A,Corvaglia L,Faldella G.Infant formulas thickened with carob bean gum causing false-positive galactomannan test reactivity.[J].2008,27(8).
[11]Stout JE,Singh N,Husain S,etc.Reactivity of platelia Aspergillus galactomannan antigen with piperacillin-tazobactam: clinical implications based on achievable concentrations in serum.[J].2004,48(6).
[12]Demiraslan, Hayati,Atalay, M. Altay,Eren, Esma,etc.Assessing the risk of false positive serum galactomannan among patients receiving piperacillin/tazobactam for febrile neutropenia[J].2017,55(5).
[13]Ramsay, Isobel,Gorton, Rebecca L.,Patel, Mauli,etc.Transmission of Hepatitis B Core Antibody and Galactomannan Enzyme Immunoassay Positivity via Immunoglobulin Products: A Comprehensive Analysis[J].2016,63(1).
[14]Cagnassi S,Musso M,Lo Nigro C,etc.False-Positive Aspergillus Galactomannan Enzyme-Linked Immunosorbent Assay Results In Vivo during Amoxicillin-Clavulanic Acid Treatment.[J].2004,42(11).
[15]Vergidis,P.,Razonable,R.R.,Wheat,L.J.,etc.Reduction in false-positive aspergillus serum galactomannan enzyme immunoassay results associated with use of piperacillin-tazobactam in the United States[J].2014,52(6).
[16]Kressel,A.K.,Vergidis,P.,Freifeld,A.G.,etc.False-positive Aspergillus galactomannan assay in solid organ transplant recipients with histoplasmosis[J].2012,14(2).
[17]Spriet, Isabel,Lagrou, Katrien,Maertens, Johan,etc.Plasmalyte: No Longer a Culprit in Causing False-Positive Galactomannan Test Results[J].2016,54(3).
[18]Mikulska,M.,Furfaro,E.,DelBono,V.,etc.Piperacillin/tazobactam (Tazocin?) seems to be no longer responsible for false-positive results of the galactomannan assay[J].2012,67(7).
[19]Kimura, Shun-ichi,Akahoshi, Yu,Nakano, Hirofumi,etc.False-positive Aspergillus galactomannan and its kinetics in allogeneic hematopoietic stem cell transplantation[J].2015,70(5).
[20]Corrado Girmenia,Daniele Ballarò,Pietro Martino.Contamination by Cardboard Particles as a Cause of False-Positive Results for Aspergillus Galactomannan Enzyme Immunoassays[J].2007,14(7).
[21]Castaigne,S.,Rigaudeau,S.,Rousselot,P.,etc.False positive galactomannan Platelia due to piperacillin-tazobactam[J].2012,42(1).
[22]Petraitiene R,Petraitis V,Witt JR 3rd,etc.Galactomannan antigenemia after infusion of gluconate-containing Plasma-Lyte.[J].2011,49(12).
[23]Viboon Boonsarngsuk,Anuchit Niyompattama,Chalermporn Teosirimongkol,etc.False-positive serum and bronchoalveolar lavage Aspergillus galactomannan assays caused by different antibiotics[J].2010,42(6-7).
[24]Tomita Y,Sugimoto M,Kawano O,etc.High incidence of false-positive Aspergillus galactomannan test results in patients with aspiration pneumonia.[J].2009,57(5).
[25]Adam, Olivier,Aupérin, Anne,Wilquin, Fanny,etc.Treatment with Piperacillin-Tazobactam and False-Positive Aspergillus Galactomannan Antigen Test Results for Patients with Hematological Malignancies.[J].2004,38(6).
[26]Sushil.Kathar,Jai.Mullerpattan,Anjali.Shetty,etc.Bronchoalveolar lavage contamination by sterile containers: A unique and unrecognized cause of a false-positive galactomannan[J].2017,34(6).
[27]Dimitrios Farmakiotis,Audrey Le,Zoe Weiss,etc.False positive bronchoalveolar lavage galactomannan: Effect of host and cut‐off value[J].2019,62(3).
[28]A J, Ullmann,J M, Aguado,S, Arikan-Akdagli,etc.Diagnosis and management of Aspergillus diseases: executive summary of the 2017 ESCMID-ECMM-ERS guideline.[J].2018,(Spec ).
[29]Yoshiaki Abe,Kentaro Narita,Hiroki Kobayashi,etc.Higher frequency of false‐positive serum galactomannan tests among older subjects and the association with elevated serum immunoglobulin G levels[J].2019,62(9).
[30]Kocmanova I,Mayer J,Lengerova M,etc.Intravenous PLASMA-LYTE as a Major Cause of False-Positive Results of Platelia Aspergillus Test for Galactomannan Detection in Serum.[J].2007,45(9).
[31]Mewis A,Cartuyvels R,Magerman K,etc.False-positive results by the platelia Aspergillus galactomannan antigen test for patients treated with amoxicillin-clavulanate.[J].2008,15(7).
[32]Bacher J,Schaufele R,Sein T,etc.Detection of Galactomannan Antigenemia in Patients Receiving Piperacillin-Tazobactam and Correlations between In Vitro, In Vivo, and Clinical Properties of the Drug-Antigen Interaction.[J].2004,42(10).
[33]Edgar,Ortiz-Brizuela,Andrea,Rangel-Cordero,Alfredo,Ponce-de-León,etc.False-positive results in the galactomannan Platelia™ Aspergillus assay with generic piperacillin/tazobactam.[J].2019,36(1).
[34]Corrado, Girmenia,Stefania, Santilli,Daniele, Ballarò,etc.Enteral nutrition may cause false-positive results of Aspergillus galactomannan assay in absence of gastrointestinal diseases.[J].2011,54(6).