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慢性阻塞性肺疾病生物标志物研究进展

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Author:: No author available

Journal Title:: Chinese Journal of Tuberculosis and Respiratory Diseases

Issue:: 4

DOI:: 10.3760/cma.j.issn.1001-0939.2019.04.011

Key Word:: No keyword available

Abstract：近年研究发现慢阻肺有不同表型,而一些生物标志物与疾病的表型、严重程度和急性加重相关.随着检测技术的发展和数据挖掘能力的提高,对慢阻肺生物标志物研究蓬勃发展,本综述通过归纳和总结近5年来与慢阻肺生物标志物研究相关的基础和临床研究,分析现有生物标志物研究方法的可行性和局限性,初步探讨已有生物标志物的可能临床价值,并展望了未来发展方向和面临的挑战.

Reference

[1]James D, Chalmers,Stefano, Aliberti,Anna, Filonenko,etc.Characterisation of the "Frequent Exacerbator Phenotype" in Bronchiectasis.[J].2018,(Spec ).
[2]Gaetano Caramori,Paolo Ruggeri,Antonino Di Stefano,etc.Autoimmunity and COPD: Clinical Implications[J].2018,153(6).
[3]Brightling,C.E.,Bleecker,E.R.,Panettieri,R.A.,etc.Benralizumab for chronic obstructive pulmonary disease and sputum eosinophilia: A randomised, double-blind, placebo-controlled, phase 2a study[J].2014,2(11).
[4]Aziz, Gumus,Nejat, Altintas,Halit, Cinarka,etc.Soluble urokinase-type plasminogen activator receptor is a novel biomarker predicting acute exacerbation in COPD.[J].2015,10.
[5]Molyneaux,P.L.,Mallia,P.,Cox,M.J.,etc.Outgrowth of the bacterial airway microbiome after rhinovirus exacerbation of chronic obstructive pulmonary disease[J].2013,188(10).
[6]Nikolakopoulou,S.,Hillas,G.,Perrea,D.,etc.Serum angiopoietin-2 and CRP levels during COPD exacerbations[J].2014,11(1).
[7]Sun Hye, Shin,Hye Yun, Park,Danbee, Kang,etc.Serial blood eosinophils and clinical outcome in patients with chronic obstructive pulmonary disease.[J].2018,19(1).
[8]Fang, Liwen,Gao, Pei,Bao, Heling,etc.Chronic obstructive pulmonary disease in China: a nationwide prevalence study[J].2018,6(6).
[9]Sohal, Sukhwinder Singh,Eapen, Mathew Suji,Ward, Chris,etc.Airway inflammation and inhaled corticosteroids in COPD[J].2017,49(6).
[10]Zemans, Rachel L.,Jacobson, Sean,Keene, Jason,etc.Multiple biomarkers predict disease severity, progression and mortality in COPD.[J].2017,18.
[11]Günay,E.,Sarin?Ula?li,S.,Akar,O.,etc.Neutrophil-to-lymphocyte ratio in chronic obstructive pulmonary disease: A retrospective study[J].2014,37(2).
[12]Alcazar-Navarrete, Bernardino,Ruiz Rodriguez, Oliverio,Romero Palacios, Pedro Jose,etc.Persistently elevated exhaled nitric oxide fraction is associated with increased risk of exacerbation in COPD[J].2018,51(1).
[13]Guoping, Hu,Yankui, Wu,Yumin, Zhou,etc.Prognostic role of D-dimer for in-hospital and 1-year mortality in exacerbations of COPD.[J].2016,(Spec ).
[14]Wenqi, Diao,Ning, Shen,Yipeng, Du,etc.Identification of thyroxine-binding globulin as a candidate plasma marker of chronic obstructive pulmonary disease.[J].2017,12(Spec ).
[15]Celli,B.R.,Locantore,N.,Yates,J.,etc.Inflammatory biomarkers improve clinical prediction of mortality in chronic obstructive pulmonary disease[J].2012,185(10).
[16].Role of eosinophils in airway inflammation of chronic obstructive pulmonary disease.[J].2018,13(Spec).
[17]Galanter, Joshua,Loyd, James E.,Himes, Blanca E.,etc.Current Status and Future Opportunities in Lung Precision Medicine Research with a Focus on Biomarkers[J].2018,198(12).
[18]Fernando Sergio,Leitao Filho,Nawaf M,Alotaibi,David,Ngan,etc.Sputum Microbiome is Associated with 1-Year Mortality Following COPD Hospitalizations.[J].2018.
[19]Bartziokas,K.,Papaioannou,A.I.,Loukides,S.,etc.Serum uric acid as a predictor of mortality and future exacerbations of COPD[J].2014,43(1).
[20]Ishii, Takeo,Motegi, Takashi,Gemma, Akihiko,etc.The Neutrophil to Lymphocyte Ratio Is Related to Disease Severity and Exacerbation in Patients with Chronic Obstructive Pulmonary Disease[J].2016,55(3).
[21].Plasma Fibrinogen as a Biomarker for Mortality and Hospitalized Exacerbations in People with COPD[J].2014.
[22]Thomsen,M.,Dahl,M.,Lange,P.,etc.Inflammatory biomarkers and comorbidities in chronic obstructive pulmonary disease[J].2012,186(10).
[23]McHugh,T.D.,Wedzicha,J.A.,Garcha,D.S.,etc.Changes in prevalence and load of airway bacteria using quantitative PCR in stable and exacerbated COPD[J].2012,67(12).
[24]Lee, Jin,Machin, Matthew,Russell, Kirsty E.,etc.Corticosteroid modulation of immunoglobulin expression and B-cell function in COPD[J].2016,30(5).
[25]Bradford, Eric,Jacobson, Sean,Varasteh, Jason,etc.The value of blood cytokines and chemokines in assessing COPD.[J].2017,18.
[26]Sin, Don D.,Celli, Bartolome,Criner, Gerard,etc.Pulmonary Vascular Involvement in Chronic Obstructive Pulmonary Disease Is There a Pulmonary Vascular Phenotype?[J].2018,198(8).
[27]Sugiyama, Toshihiro.A multi-organ loss of tissue phenotype in COPD: involvement of the functional muscle-bone unit[J].2018,51(6).
[28]Min, Zhu,Ting, Wang,Chengdi, Wang,etc.The association between vitamin D and COPD risk, severity, and exacerbation: an updated systematic review and meta-analysis.[J].2016,(Spec ).
[29]Itzhak, Brook,Alan E, Gober.Recovery of potential pathogens and interfering bacteria in the nasopharynx of otitis media-prone children and their smoking and nonsmoking parents.[J].2005,131(6).
[30]Goodnight-White S,Huh J,Green L,etc.Antielastin autoimmunity in tobacco smoking-induced emphysema.[J].2007,13(5).
[31]Durham, Andrew L.,Caramori, Gaetano,Chung, Kian F.,etc.Targeted anti-inflammatory therapeutics in asthma and chronic obstructive lung disease[J].2016,167(1).
[32]Vogelmeier, Claus F.,Criner, Gerard J.,Martinez, Fernando J.,etc.Global Strategy for the Diagnosis, Management, and Prevention of Chronic Obstructive Lung Disease 2017 Report: GOLD Executive Summary[J].2017,49(3).
[33]Sin, Don D.,Hollander, Zsuzsanna,DeMarco, Mari L.,etc.Biomarker Development for Chronic Obstructive Pulmonary Disease From Discovery to Clinical Implementation[J].2015,192(10).
[34]Joo-Hyun, Park,Hye Kyeong, Park,Hoon, Jung,etc.Parathyroid Hormone as a Novel Biomarker for Chronic Obstructive Pulmonary Disease: Korean National Health and Nutrition Examination Survey.[J].2015,10.
[35]Yun, Jeong H.,Lamb, Andrew,Chase, Robert,etc.Blood eosinophil count thresholds and exacerbations in patients with chronic obstructive pulmonary disease[J].2018,141(6).