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特发性肺纤维化的肺部微生态研究进展

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Author:: No author available

Journal Title:: Chinese Journal of Tuberculosis and Respiratory Diseases

Issue:: 3

DOI:: 10.3760/cma.j.issn.1001-0939.2018.03.017

Key Word:: No keyword available

Abstract：特发性肺纤维化(idiopathic pulmonary fibrosis,IPF)是一种病因不明、进展迅速、不可逆且预后极差的肺部疾病,患者的5年生存率仅为20％,甚至低于一些肿瘤疾病[1].目前普遍认为,异常的损伤-修复反应造成的反复肺泡损伤是该病的主要原因.研究结果显示,环境和宿主之间的相互作用在IPF的发生和发展中起到一定的作用[2],特别是微生物感染因素在IPF发病与进展中具有重要的意义.由于传统病原学培养技术的局限性,既往认为健康人的下呼吸道是无菌的,但是随着新一代不依赖培养的高通量测序技术的发展,越来越多的研究结果表明,在肺部存在着多样化的菌群,即肺部微生态.目前多数研究结果显示,肺部微生物菌群在多种呼吸系统疾病中出现了改变.

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