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肥胖低通气综合征稳定期的无创正压通气治疗策略
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- Author:
- No author available
- Journal Title:
- Chinese Journal of Tuberculosis and Respiratory Diseases
- Issue:
- 9
- DOI:
- 10.3760/cma.j.issn.1001-0939.2017.09.006
- Key Word:
- No keyword available
Abstract： 近年来,越来越多的学者开始重视肥胖低通气综合征(obesity hypoventilation syndrome,OHS)的诊断和治疗,OHS稳定期患者的家庭无创正压通气治疗是重要的治疗手段.OHS是病态肥胖的严重并发症之一,约90％的OHS患者同时存在阻塞性睡眠呼吸暂停综合征(obstructive sleep apnea,OSA).OHS的发生率随着肥胖显著增高,在OSA中的发病率为10％～20％,而在体重指数＞35 kg/m2的住院人群中发病率为31％[1-2].OHS可导致患者生活质量明显下降,社会经济负担增加,医疗费用增加,比单纯OSA患者的致病率和病死率更高[3].与单纯肥胖的患者相比,OHS患者预后更差,严重的OHS住院患者中病死率高达50％,与没有低通气综合征的同样肥胖的患者相比,OHS患者ICU入住率高,且对无创通气的需要增加.
- [1]Dan Adler,Jean-Christian Borel,Olivier Contal.Impact of Different Backup Respiratory Rates on the Efficacy of Noninvasive Positive Pressure Ventilation in Obesity Hypoventilation Syndrome A Randomized Trial[J].2013,143(1).
- [2]Wang D,Grunstein RR,Barnes DJ,etc.Randomised trial of CPAP vs bilevel support in the treatment of obesity hypoventilation syndrome without severe nocturnal desaturation.[J].2008,63(5).
- [3]Juan F, Masa,Jaime, Corral,Maria L, Alonso,etc.Efficacy of Different Treatment Alternatives for Obesity Hypoventilation Syndrome. Pickwick Study.[J].2015,192.
- [4]Piper, Amanda.Obesity Hypoventilation Syndrome Weighing in on Therapy Options[J].2016,149(3).
- [5]Olalla, Castro-A?ón,Luis A, Pérez de Llano,Sandra, De la Fuente Sánchez,etc.Obesity-hypoventilation syndrome: increased risk of death over sleep apnea syndrome.[J].2015,10(2).
- [6]Metzger M,Sforza E,Janssens JP.Impact of volume targeting on efficacy of bi-level non-invasive ventilation and sleep in obesity-hypoventilation.[J].2009,103(2).
- [7]Mokhlesi B,Tulaimat A,Wang Y,etc.Obesity hypoventilation syndrome: prevalence and predictors in patients with obstructive sleep apnea.[J].2007,11(2).
- [8]Davidson Ward SL,Morgenthaler T,Brown LK,etc.Best clinical practices for the sleep center adjustment of noninvasive positive pressure ventilation (NPPV) in stable chronic alveolar hypoventilation syndromes.[J].2010,6(5).
- [9]Elena, Ojeda Castillejo,Pilar, de Lucas Ramos,Soledad, López Martin,etc.Noninvasive mechanical ventilation in patients with obesity hypoventilation syndrome. Long-term outcome and prognostic factors.[J].2015,51(2).
- [10]Sogol Nowbar,Kristin M Burkart,Ralph Gonzales,etc.Obesity-Associated hypoventilation in hospitalized patients: prevalence, effects, and outcome[J].2004,116(1).
- [11].Noninvasive ventilation in acute hypercapnic respiratory failure caused by obesity hypoventilation syndrome and chronic obstructive pulmonary disease[J].2012,186(12).
- [12]D'Ambrosio C,Trentin R,Taurino AE,etc.Effect of sleep on patient/ventilator asynchrony in patients undergoing chronic non-invasive mechanical ventilation.[J].2007,101(8).
- [13]Yan Fei Guo,Emilia Sforza,Jean Paul Janssens.Respiratory Patterns During Sleep in Obesity-Hypoventilation Patients Treated With Nocturnal Pressure Support: A Preliminary Report[J].2007,131(4).