You Position: Home > Paper
乌司他丁对支气管哮喘小鼠氧化应激及血红素加氧酶-1的影响
( views:259, downloads:136 )
- Author:
- No author available
- Journal Title:
- Chinese Journal of Tuberculosis and Respiratory Diseases
- Issue:
- 3
- DOI:
- 10.3760/cma.j.issn.1001-0939.2013.03.020
- Key Word:
- No keyword available
Abstract： 乌司他丁(Ulinastatin)是一种高效广谱水解酶抑制剂[1-2],临床上已广泛应用于弥漫性血管内凝血、急性肺损伤等炎性疾病的治疗[3-4],但其在过敏性哮喘中的抗氧化作用及其与血红素加氧酶-1(heme oxygenase-1,HO-1)的关系尚不明了本研究中从氧化应激角度探讨乌司他丁在卵清白蛋白(OVA)诱导的支气管哮喘(简称哮喘)小鼠模型中的作用及其与HO-1的关系,为探寻新的高效安全的临床哮喘治疗药物提供线索.
- [1]沈华浩,王苹莉.支气管哮喘小鼠模型应用评价[J].2005,(4).
- [2]袁红,郑静晨,刘平,等.帕金森病的发病机理：氧化应激，环境影响因素与神经炎症[J].2007,(2).
- [3]Agnieszka, Szlagatys-Sidorkiewicz,Magdalena, Góra-Gebka,Maria, Korzon.[Reactive oxygen species and antioxidative barrier in asthma].[J].2007,75(2).
- [4]Min Soo, Kim,Jung Woo, Park,Yun Hee, Lim,etc.Effect of ulinastatin on the rocuronium-induced neuromuscular blockade.[J].2012,62(3).
- [5]John A, Marwick,Paul A, Kirkham,Christopher S, Stevenson,etc.Cigarette smoke alters chromatin remodeling and induces proinflammatory genes in rat lungs.[J].2004,31(6).
- [6]L C, Saalu.The incriminating role of reactive oxygen species in idiopathic male infertility: an evidence based evaluation.[J].2010,13(9).