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Update review:using fractional exhaled nitric oxide for the diagnosis and treatment of asthma

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Author:: No author available

Journal Title:: CHINESE JOURNAL OF TUBERCULOSIS AND RESPIRATORY DISEASES

Issue:: 3

DOI:: 10.3760/cma.j.issn.1001-0939.2011.03.015

Key Word:: No keyword available

Abstract： @@ 支气管哮喘(简称哮喘)是常见的慢性呼吸道疾病,气道慢性炎症是哮喘的标志性特征[1],临床上迫切需要能客观地反映气道炎症的检测技术来指导哮喘的诊断和治疗.呼出气一氧化氮(fractional exhaled nitric oxide,FENO)浓度测定是目前最有应用和研究前景的哮喘气道炎症标志物之一.目前研究结果证实,哮喘患者的FENO水平与嗜酸粒细胞性气道炎症具有良好的相关性[2].全球哮喘防治创议(GINA)[1]及我国支气管哮喘防治指南[3]也已把FENO与痰液炎症细胞检测一起列入哮喘气道炎症的无创标志物.FENO测定具有无创、快速、简便、重复性好等优点,因此它作为哮喘的炎症标志物具有独特的优势.下面就FENO测定在哮喘诊断和治疗中的应用进展进行综述.

Reference

[1]中华医学会呼吸病学分会哮喘学组.支气管哮喘防治指南（支气管哮喘的定义、诊断、治疗和管理方案）[J].2008,(3).
[2]Kulka R,Kovesi T,Dales R.Exhaled nitric oxide concentration is affected by age, height, and race in healthy 9- to 12-year-old children.[J].2008,133(1).
[3]Peche R,Louis R,Baldassarre S,etc.Exhaled nitric oxide as a marker of asthma control in smoking patients.[J].2009,33(6).
[4]Marcello, Verini,Nicola Pietro, Consilvio,Sabrina, Di Pillo,etc.FeNO as a Marker of Airways Inflammation: The Possible Implications in Childhood Asthma Management.[J].2010,2010.
[5]Carballada F,Baloira A,Boquete M,etc.Exhaled nitric oxide predicts control in patients with difficult-to-treat asthma.[J].2010,35(6).
[6]van-Asch CJ,Schilder AG,Balemans WA,etc.Atopic disease and exhaled nitric oxide in an unselected population of young adults.[J].2008,100(1).
[7]J M, Sippel,W E, Holden,S A, Tilles,etc.Exhaled nitric oxide levels correlate with measures of disease control in asthma.[J].2000,106(4).
[8]Shaw DE,Wardlaw AJ,Berry MA,etc.The use of exhaled nitric oxide to guide asthma management: a randomized controlled trial.[J].2007,176(3).
[9]Bommarito L,Guida G,Bucca C,etc.Exhaled nitric oxide in a population sample of adults.[J].2008,75(4).
[10]Burgess S,Knight D,Horak F,etc.Epithelial inducible nitric oxide synthase activity is the major determinant of nitric oxide concentration in exhaled breath.[J].2004,59(9).
[11]Dehlink E,Uxa S,Horak F Jr,etc.Exhaled nitric oxide in the management of childhood asthma: a prospective 6-months study.[J].2006,41(9).
[12]Tanou K,Koutsokera A,Papaioannou AI,etc.Portable exhaled nitric oxide as a screening tool for asthma in young adults during pollen season.[J].2008,133(4).
[13]Sivan Y,Fireman E,Gadish T.The use of exhaled nitric oxide in the diagnosis of asthma in school children.[J].2009,155(2).
[14]Baraldi E.Daily telemonitoring of exhaled nitric oxide and symptoms in the treatment of childhood asthma.[J].2009,179(2).
[15]Mitchell H,Eggleston PA,Curry MD,etc.Management of asthma based on exhaled nitric oxide in addition to guideline-based treatment for inner-city adolescents and young adults: a randomised controlled trial.[J].2008,372(9643).
[16]Shirtcliffe P,Aldington S,Weatherall M,etc.Reference ranges for exhaled nitric oxide derived from a random community survey of adults.[J].2007,176(3).
[17]Hop WC,De Jongste JC,Pijnenburg MW,etc.Titrating steroids on exhaled nitric oxide in children with asthma: a randomized controlled trial.[J].2005,172(7).
[18]William S, Linn,Edward B, Rappaport,Kiros T, Berhane,etc.Exhaled nitric oxide in a population-based study of southern California schoolchildren.[J].2009,10.
[19]Carraro S,Baraldi E,Bisgaard H,etc.Measurements of exhaled nitric oxide in healthy subjects age 4 to 17 years.[J].2005,115(6).
[20]S A, Kharitonov,D, Yates,P J, Barnes.Increased nitric oxide in exhaled air of normal human subjects with upper respiratory tract infections.[J].1995,8.
[21]Smith AD,Cowan JO,Brassett KP,etc.Use of exhaled nitric oxide measurements to guide treatment in chronic asthma.[J].2005,352(21).
[22]Jane Grundy,Abid Raza,Martha Scott,etc.Influence of atopy and asthma on exhaled nitric oxide in an unselected birth cohort study[J].2010,65(3).
[23]Kao C,Majid H.Utility of exhaled nitric oxide in the diagnosis and management of asthma.[J].2010,16(1).
[24]Tomasiak MM,Szmitkowski M,Zietkowski Z,etc.Comparison of exhaled nitric oxide measurement with conventional tests in steroid-naive asthma patients.[J].2006,16(4).