You Position: Home > Paper
The research progress of fibroblast foci in idiopathic pulmonary fibrosis
( views:380, downloads:188 )
- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF TUBERCULOSIS AND RESPIRATORY DISEASES
- Issue:
- 3
- DOI:
- 10.3760/cma.j.issn.1001-0939.2009.03.010
- Key Word:
- No keyword available
Abstract： @@ 特发性肺纤维化(idiopathic pulmonary fibrosis,IPF)是最常见的一种间质性肺疾病,目前其发病机制仍不十分明确,病理特征是各种原因所导致的肺泡上皮细胞损伤和不正常的组织修复,从而导致肺部正常组织结构的破坏,代之以异常增生的成纤维细胞及肌成纤维细胞,即形成所谓的成纤维细胞灶(fibroblast foci)[1],这些细胞分泌大量细胞外基质及合成胶原纤维,最终导致肺纤维化的形成[2].成纤维细胞灶是IPF的重要病理特征,成纤维细胞灶数最的增加是IPF进展和预后不良的重要因素[3].因此,近年来关于成纤维细胞灶的功能、细胞来源、调控因素等逐渐成为研究的热点.现将成纤维细胞灶的研究进展进行综述.
- [1]Pardo A,Tollefsbol TO,Hagood JS,etc.Thy-1 promoter hypermethylation: a novel epigenetic pathogenic mechanism in pulmonary fibrosis.[J].2008,39(5).
- [2]Mak TW,Hogaboam CM,Kontos CD,etc.Negative Regulation of Myofibroblast Differentiation by PTEN (Phosphatase and Tensin Homolog Deleted on Chromosome 10).[J].2006,173(1).
- [3]Gyetko MR,Phan SH,Hu B,etc.New insights into the pathogenesis and treatment of idiopathic pulmonary fibrosis: a potential role for stem cells in the lung parenchyma and implications for therapy.[J].2007,24(5).
- [4]Thannickal V. J.,Fanburg B. L..Activation of an H2O2-generating NADH Oxidase in Human Lung Fibroblasts by Transforming Growth Factor\u00a01[J].1995.
- [5]Elisabetta A, Renzoni,David J, Abraham,Sarah, Howat,etc.Gene expression profiling reveals novel TGFbeta targets in adult lung fibroblasts.[J].2004,5.
- [6]Liu T,Phan SH,Hashimoto N,etc.Bone marrow-derived progenitor cells in pulmonary fibrosis.[J].2004,113(2).
- [7]Fulford LG,du Bois RM,Colby TV,etc.The relationship between individual histologic features and disease progression in idiopathic pulmonary fibrosis.[J].2002,166(2).
- [8]Radford K,Leigh R,Martin GE,etc.Cell-specific gene expression in patients with usual interstitial pneumonia.[J].2006,174(5).
- [9]Zavadil J,Bottinger EP.TGF-beta and epithelial-to-mesenchymal transitions.[J].2005,24(37).
- [10]Sanders YY,Kumbla P,Hagood JS.Enhanced myofibroblastic differentiation and survival in Thy-1(-) lung fibroblasts.[J].2007,36(2).
- [11]Jeffery R,Forbes SJ,Alison MR,etc.Multiple organ engraftment by bone-marrow-derived myofibroblasts and fibroblasts in bone-marrow-transplanted mice.[J].2003,21(5).
- [12]Watanabe M,Arimura K,Higashimoto I,etc.Discoidin domain receptor 1 contributes to the survival of lung fibroblast in idiopathic pulmonary fibrosis.[J].2006,168(3).