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Different cytokine profiles in usual interstitial pneumonia and nonspecific interstitial pneumonia
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- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF TUBERCULOSIS AND RESPIRATORY DISEASES
- Issue:
- 6
- DOI:
- 10.3760/j:issn:1001-0939.2003.06.011
- Key Word:
- 普通型间质性肺炎;非特异性间质性肺炎;转化生长因子β;成纤维细胞生长因子,碱性;白细胞介素类;干扰素Ⅱ型
Abstract： 目的研究转化生长因子(TGF)β1、碱性成纤维细胞生长因子(b-FGF)、白细胞介素8(IL-8)、白细胞介素13(IL-13)、γ干扰素(IFN-γ)在普通型间质性肺炎(UIP)和非特异性间质性肺炎(NSIP)肺组织中的分布、表达及意义.方法经胸腔镜或开胸肺活检获取5例UIP和8例NSIP患者的肺组织.对照组5例,来自手术切除的远离肺癌原发灶的周边肺组织.用免疫组化法半定量分析细胞因子的分布及表达.结果TGF-β1、IL-8、b-FGF主要分布在肺泡上皮细胞、肺泡巨噬细胞、细支气管上皮细胞,UIP组表达强于NSIP组和对照组.IL-13主要分布在肺泡上皮细胞、肺泡巨噬细胞、间质单个核细胞,UIP、NSIP组表达无明显差异,但均强于对照组.IFN-γ主要分布在间质单个核细胞,NSIP组表达强于UIP组和对照组.UIP组的IL-13/IFN-γ比值为(2.18±0.76),NSIP组为(0.95±0.28),对照组为(0.91±0.16),3组比较差异均有显著性(P值均＜0.05),而NSIP组与对照组比较差异无显著性.对照组只有肺泡巨噬细胞表达上述各细胞因子.结论TGF-β1、IL-8、b-FGF在UIP和NSIP患者肺组织中表达强度的不同和IL-13/IFN-γ的是否平衡可能参与了UIP和NSIP不同的发病过程.
- [1]M, Turner-Warwick,P L, Haslam.The value of serial bronchoalveolar lavages in assessing the clinical progress of patients with cryptogenic fibrosing alveolitis.[J].1987,135.
- [2]Anton M. Jetten,Jill E. Shirley,Gary Stoner.Regulation of proliferation and differentiation of respiratory tract epithelial cells by TGFβ[J].1986,167(2).
- [3]ZIEGENHAGEN MANFRED W.,ZABEL PETER,ZISSEL GERNOT,etc.Serum Level of Interleukin 8 Is Elevated in Idiopathic Pulmonary Fibrosis and Indicates Disease Activity[J].1998.
- [4]Strieter RM,Wilke CA,Whyte RI,etc.The CXC chemokines, IL-8 and IP-10, regulate angiogenic activity in idiopathic pulmonary fibrosis.[J].1997,159(3).
- [5]Essayan DM,Huang SK,Lichtenstein LM,etc.Interleukin-13 modulates collagen homeostasis in human skin and keloid fibroblasts.[J].2000,292(3).
- [6]Lynch Joseph P. "suffix":"III,Standiford Theodore J.,Rolfe Mark W.,etc.Neutrophilic Alveolitis in Idiopathic Pulmonary Fibrosis: The Role of Interleukin-8[J].1992.
- [7]Sime PJ,O'Reilly KM.Fibrosis of the lung and other tissues: new concepts in pathogenesis and treatment.[J].2001,99(3).