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Evaluation of thrombolytic therapy by pulmonary radionuclide perfusion imaging in patients with acute pulmonary thromboembolism
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- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF TUBERCULOSIS AND RESPIRATORY DISEASES
- Issue:
- 2
- DOI:
- 10.3760/j:issn:1001-0939.2003.02.005
- Key Word:
- 肺灌注显像;溶栓治疗;急性肺血栓栓塞症
Abstract： 目的应用核素肺灌注显像评价急性肺血栓栓塞症患者溶栓前后肺血流灌注的变化情况.方法 80例急性肺栓塞患者溶栓前后均行肺灌注显像.应用半定量法分析图像,计算灌注缺损百分数(PPDs),溶栓前、溶栓后1～5 d、6～30 d和3个月以上PPDs分别表示为PPDsD0、PPDsD5 、PPDsD30和PPDsM3.结果全部80例患者PPDsD0平均为(57.3±16.4)%.其中64例溶栓前PPDsD0为(55.5±16.8)%,溶栓后早期PPDs明显降低,PPDsD5为(40.0±18.6)%,两者比较P<0.001.其中30例PPDsD0, PPDsD5和PPDsD30 分别为 (57.5±16.1)%,( 39.3±16.8)%和(29.5±17.3)%,三者之间差异均有显著性,均为P<0.001.溶栓3个月以后,PPDs仍有一定程度的减低,11例患者PPDsD30和PPDsM3分别为(40.9±18.1)%和(29.1±27.1)%,P<0.05.病程在7天以内和病程在8～14天的两组患者溶栓后PPDs均有十分明显的降低;而病程在14天以上的患者,溶栓后PPDs也有一定程度的降低,但降低的程度小于前两组患者.结论应用肺灌注显像可以准确观察溶栓后肺血流灌注的动态变化过程,是评价急性肺栓塞溶栓疗效的简便可靠的常规方法.
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