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Application of 123/131I-MIBG in the diagnosis and treatment of pediatric neuroblastoma

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Author:
No author available
Journal Title:
Chinese Journal of Nuclear Medicine and Molecular Imaging
Issue:
3
DOI:
10.3760/cma.j.issn.2095-2848.2017.03.013
Key Word:
神经母细胞瘤;碘放射性同位素;3-碘苄胍;发展趋势;Neuroblastoma;Iodine radioisotopes;3-Iodobenzylguanidine;Trends

Abstract: As a type of neuroendocrine tumors,neuroblastoma (NB) is the most common extra-cranial solid tumor of childhood.123/131I-MIBG scintigraphy is a standard imaging modality in staging and evaluating therapeutic effect of pediatric NB with high accuracy.131I-MIBG treatment is effective for children with high-risk and relapsed/refractory NB.Combined with chemotherapy,stem cell transplantation,131I-MIBG treatment shows efficacy in decreasing the relapse of pediatric NB.This review summarizes the application of MIBG scintigraphy and 131I-MIBG treatment for pediatric NB.

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