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Radionuclide molecular probe for the diagnosis and target therapy of malignant melanoma

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Author:: No author available

Journal Title:: Chinese Journal of Nuclear Medicine and Molecular Imaging

Issue:: 5

DOI:: 10.3760/cma.j.issn.2095-2848.2016.05.022

Key Word:: 黑色素瘤;诊断;分子靶向治疗;分子探针;同位素标记;发展趋势;Melanoma;Diagnosis;Molecular targeted therapy;Molecular probes;Isotope labeling;Trends

Abstract： Early diagnosis and accurate staging are important for planning therapeutic intervention to improve outcomes in patients with malignant melanoma (MM).Noninvasive molecular imaging has been extensively studied in cancer diagnosis,staging,therapeutic evaluation,and prognosis.Several radiopharmaceuticals have been developed to diagnose and treat MM,such as monoclonal antibodies,melanocortin receptors,benzamide (BZA) and BZA analogs.In this review,the characteristics and limitations of these radionuclide molecular probes are summarized and discussed.

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