Correlation research of renal perfusion and diffusion function using MRI in renal allograft early after renal transplantation
- Author:
- No author available
- Journal Title:
- Chinese Journal of Radiology
- Issue:
- 9
- DOI:
- 10.3760/cma.j.issn.1005-1201.2017.09.012
- Key Word:
- 肾移植;肾机能不全;磁共振成像;Kidney transplantation;Renal insufficiency;Magnetic resonance imaging
Abstract： Objective To explore the correlationships between microperfusion diffusion indexes derived from intravoxel incoherent motion(IVIM)and perfusion values measured by arterial spin labeling (ASL)in renal allograft. Methods A total of 76 renal allograft recipients and 26 age-matched volunteers (group 0)were included in this prospective study. All subjects were underwent conventional MRI, IVIM and ASL MRI which were performed in the oblique-sagittal plane. Seventy-six recipients were divided into two groups based on the estimated glomerular filtration rate(eGFR):recipients with good allograft function(group 1, eGFR≥ 60 ml · min-1 · 1.73m-2,n=44)and recipients with impaired allograft function(group 2, eGFR<60 ml · min-1 · 1.73m-2,n=32). Three IVIM indexes values, including true diffusion coefficient(ADCslow), pseudo-diffusion coef fi cient(ADCfast), perfusion fraction(PF), and one ASL index value of renal cortex(renal blood flow, RBF)were measured. One-way analysis of variance and the least significant difference were used to compare the different of each cortical index values among three groups. Correlations between the ADCslow, ADCfast, PF, RBF and eGFR as well as the correlation among the indexes were evaluated using Pearson correlation coefficients. Results For cortical ADCslow, ADCfast, PF and RBF values, allografts with good function and impaired function showed significantly differences compared healthy controls(all P<0.01). In allografts with good function, cortical ADCslow,ADCfast,PF showed no significantly differences compared with controls(all P>0.05), but RBF value was significantly lower(P<0.05). The ADCslow, ADCfast, PF and RBF values of renal cortex were significantly lower in allografts with impaired function compared to allografts with good function(all P<0.01). In renal allografts, there were significant positive correlations between cortical ADCslow, ADCfast, PF, RBF value and eGFR(r values were 0.604, 0.552, 0.579 and 0.673, all P<0.01). Cortical ADCfast and PF value exhibited a significant correlation with RBF for recipients(r values were 0.501 and 0.423, all P<0.01). Conclusion Cortical ADCfast and PF values derived from IVIM and RBF measured by ASL show a significant positive correlation in renal allografts.
- [1]张斌,陈文波,梁龙,等.基于体素内不相干运动的扩散加权成像评估对比剂急性肾损伤肾功能动态变化的可行性[J].2016,(3).
- [2]邹倩,罗城,龚良庚.基于体素内不相干运动的扩散加权成像在肾脏疾病中的应用进展[J].2016,(3).
- [3]黄智敏,毛慧娟,俞香宝,等.慢性肾衰竭非透析患者心血管并发症的相关因素分析[J].2013,(10).
- [4]J-C, Ferré,E, Bannier,H, Raoult,etc.Arterial spin labeling (ASL) perfusion: Techniques and clinical use.[J].2013,94(12).
- [5]Thoeny HC,Zumstein D,Simon-Zoula S,etc.Functional evaluation of transplanted kidneys with diffusion-weighted and BOLD MR imaging: initial experience.[J].2006,241(3).
- [6]Vermathen,P.,Binser,T.,Boesch,C.,etc.Three-year follow-up of human transplanted kidneys by diffusion-weighted MRI and blood oxygenation level-dependent imaging[J].2012,35(5).
- [7]Chandarana H,Hecht E,Sigmund EE,etc.Comparison of biexponential and monoexponential model of diffusion weighted imaging in evaluation of renal lesions: preliminary experience.[J].2011,46(5).
- [8]Feifei, Lin,Zhiyong, Li,Yungen, Gan,etc.Relationship between renal apparent diffusion coefficient values and glomerular filtration rate in infants with congenital hydronephrosis.[J].2014,8(5).
- [9]Artz NS,Sadowski EA,Wentland AL,etc.Reproducibility of renal perfusion MR imaging in native and transplanted kidneys using non-contrast arterial spin labeling.[J].2011,33(6).
- [10]Ebrahimi,B.,Textor,S.C.,Lerman,L.O..Renal relevant radiology: Renal functional magnetic resonance imaging[J].2014,9(2).
- [11]Kr?pil,P.,Wittsack,H.-J.,Bilk,P.,etc.Correlation of biexponential diffusion parameters with arterial spin-labeling perfusion MRI: Results in transplanted kidneys[J].2013,48(3).
- [12]Heusch,P.,Wittsack,H.-J.,Blondin,D.,etc.Functional evaluation of transplanted kidneys using arterial spin labeling MRI[J].2014,40(1).
- [13]Thoeny HC,Frey FJ,Boesch C,etc.Evaluation of renal allograft function early after transplantation with diffusion-weighted MR imaging.[J].2010,20(6).
- [14].K/DOQI clinical practice guidelines for chronic kidney disease: evaluation, classification, and stratification.[J].2002,39(2 Suppl 1).
- [15]Levy AR,Jardine A,Wu O,etc.Acute rejection and chronic nephropathy: a systematic review of the literature.[J].2009,87(9).
- [16]Ott,C.,Janka,R.,Schmid,A.,etc.Vascular and renal hemodynamic changes after renal denervation[J].2013,8(7).
- [17]Akta?,A..Transplanted kidney function evaluation[J].2014,44(2).
- [18]Martirosian P,Kropil P,Bilk P,etc.Quantification of renal allograft perfusion using arterial spin labeling MRI: initial results.[J].2010,20(6).
- [19]Meier Kriesche HU,Lodhi SA.Kidney allograft survival: the long and short of it.[J].2011,26(1).
- [20]Artz, N.S.,Sadowski, E.A.,Wentland, A.L.,etc.Arterial spin labeling MRI for assessment of perfusion in native and transplanted kidneys[J].2011,29(1).
- [21]McIntyre,C.W.,Odudu,A.,Francis,S.T..MRI for the assessment of organ perfusion in patients with chronic kidney disease[J].2012,21(6).
- [22]Martirosian P,Miller S,Claussen CD,etc.Perfusion MR imaging with FAIR true FISP spin labeling in patients with and without renal artery stenosis: initial experience.[J].2006,238(3).
- [23]Vapaatalo H,Lahteenmaki T,Vaskonen T,etc.Effects of ACE inhibition on cyclosporine A-induced hypertension and nephrotoxicity in spontaneously hypertensive rats on a high-sodium diet.[J].1999,8(1).