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冠状动脉易损斑块的CT研究进展

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Author:: No author available

Journal Title:: Chinese Journal of Radiology

Issue:: 9

DOI:: 10.3760/cma.j.issn.1005-1201.2012.09.018

Key Word:: No keyword available

Abstract：急性冠状动脉综合征(acute coronary syndrome,ACS)[1 ]是指由于冠状动脉急性病变致冠状动脉严重狭窄或闭塞所产生的一组临床综合征,包括不稳定性心绞痛( UAP)、非ST段抬高性心肌梗死(NSTEMI)及ST段抬高性心肌梗死(STEMI).研究发现,大多数ACS患者的冠状动脉狭窄并不严重,68％的ACS是由狭窄程度＜50％的斑块引起[2].近年来的研究表明,冠状动脉粥样斑块在进展过程中由于血管重构可无管腔严重狭窄,但可能发生斑块破裂、继发血栓形成,致急性管腔严重狭窄或闭塞,临床发生ACS[3].这种易于破裂的斑块称为易损斑块( vulnerable plaque,VP),它是ACS的病理基础.目前ACS的诊断主要依赖于临床症状、心电图及心肌坏死标记物,诊断及治疗均在ACS发生之后,如果能在ACS发生前识别易损斑块并采取相应干预措施将可能使患者获益更充分.

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