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The long-term efficacy of interventional combined therapy for osteosarcoma of the extremities
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- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF RADIOLOGY
- Issue:
- 10
- DOI:
- 10.3760/j.issn:1005-1201.2004.10.005
- Key Word:
- 骨肿瘤;放射学,介入性;放射疗法;综合疗法;评价研究
Abstract： 目的分析介入性综合治疗方法治疗肢体骨肉瘤的效果.方法对55例经病理证实的肢体骨肉瘤给予3个阶段性的治疗:(1)经动脉局部灌注及全身化疗2个疗程.(2)动脉内局部小剂量灌注同时放疗.(3)全身化疗6个疗程.所有病例随访12～210个月.按完成治疗阶段分A、B、C 3组;A组完成全部3个阶段的治疗,B组完成第1、2阶段的治疗,C组仅完成第1阶段的治疗.回顾分析3组患者的肿瘤局部控制率、累计生存率和中位生存期.结果 A、B两组总的局部控制率为 86.36%,局部复发率为 13.64%.1、3、5年的累计生存率分别为A组100.00%、71.43%、53.19%,B组81.25%、6.25%、6.25%;C组1年生存率为27.27%,第2年全部死亡.3个组的中位生存期(含带瘤)为:A组62.23个月、B组20.57个月、C组8.25个月,差异有非常显著性意义(A组与B组比较:χ2=28.58, P<0.0001; A组与C组比较:χ2=53.95,P<0.0001 ;B组与C组比较:χ2=16.39, P<0.0001).结论对肢体骨肉瘤进行介入性综合治疗能获得良好的肿瘤局部控制率及较好的远期生存率.
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