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转化生长因子β1及其受体基因多态性与原因不明复发性流产的关系
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- Author:
- No author available
- Journal Title:
- Chinese Journal of Obstetrics and Gynecology
- Issue:
- 4
- DOI:
- 10.3760/cma.j.issn.0529-567x.2017.04.009
- Key Word:
- No keyword available
Abstract： 原因不明复发性流产(unexplained recurrent spontaneous abortion,URSA)是指发生连续2次以上病因不明的自然流产,其病因十分复杂[1-2].转化生长因子β1(transforming growth factor-β1,TGF-β1)通过TGF-β受体(TGF-βR)传导信号发挥生物学效应,是1种重要的滋养细胞的负性免疫平衡调节因子,与妊娠早期的胚胎着床及胎盘形成密切相关[3].近年的研究认为,TGF-β1和TGF-βR基因的单核苷酸多态性(single nucleotide polymorphism,SNP)具有地域、民族及种族间的差异性,其基因多态性与URSA易感性关系的研究结果不一致[4-5].本研究采用基质辅助激光解吸电离飞行时间质谱(matrix-assisted laser desorption/ionization time of flight mass spectrometry,MALDI TOF MS)技术分析URSA患者TGF-β1基因C-509T、TGF-βR1基因Int7 G24A和TGF-βR2基因G-875A的多态性,通过病例对照研究,从遗传学和生殖免疫学角度探讨URSA的发生机制.
- [1]郑加永,张红萍,徐晓敏,等.人类白细胞抗原DQ基因多态性与不明原因复发性流产的关联分析[J].2016,(1).
- [2]李霞.TGF-β1基因多态性与反复自然流产（RSA）的关联性研究[D].2011.
- [3]金艳慧,沈晓露,王明山,等.凝血因子Ⅻ基因C46T多态性与原因不明复发性流产及凝血因子Ⅻ活性的关系[J].2016,(8).
- [4]Amani D,Dehaghani AS,Yoshiura K,etc.Lack of association between the TGF-beta1 gene polymorphisms and recurrent spontaneous abortion.[J].2005,68(1).
- [5]Enshi Wang,Zhenhua Wang,Shenghua Liu,etc.Polymorphisms of VEGF, TGFβ1, TGFβR2 and conotruncal heart defects in a Chinese population[J].2014,41(3).
- [6]Jue Wang,Yu Nie,YuJian Zhang,etc.Methylenetetrahydrofolate reductase C677T and reduced folate carrier 80 G>A polymorphisms are associated with an increased risk of conotruncal heart defects.[J].2012,50(8).
- [7]Morrish, D. W.,Dakour, J.,Li, H..Life and Death in the Placenta: New Peptides and Genes Regulating Human Syncytiotrophoblast and Extravillous Cytotrophoblast Lineage Formation and Renewal.[J].2001,2(3).
- [8]Amani D,Ghaderi A,Dehaghani AS,etc.The promoter region (-800, -509) polymorphisms of transforming growth factor-beta1 (TGF-beta1) gene and recurrent spontaneous abortion.[J].2004,62(1).
- [9]Magdoud,K.,Mahjoub,T.,Herbepin,V.G.,etc.Genetic variation in TGFBI gene and risk of idiopathic recurrent pregnancy loss[J].2013,19(7).
- [10]Hye-Jin Ki,Se Yun Kim,Sang Ho Lee,etc.Transforming growth factor-β receptor 2 gene polymorphisms are associated with end-stage renal disease[J].2015,34(2).