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环孢素A调节妊娠的分子机制研究进展

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Author:: No author available

Journal Title:: Chinese Journal of Obstetrics and Gynecology

Issue:: 12

DOI:: 10.3760/cma.j.issn.0529-567x.2016.12.014

Key Word:: No keyword available

Abstract：环孢素A(cyclosporin A, CsA)是大环内酯类免疫抑制剂，广泛应用于器官移植后排斥反应和自身免疫性疾病的防治。近年的研究表明，CsA在0.0001～1μmol/L浓度范围内可有效促进早孕期细胞滋养细胞的增殖和侵袭能力[1]；动物研究也发现，低剂量CsA（1～10 mg/kg）可明显降低自然流产模型小鼠的胚胎吸收率[2]；国内学者近年来也尝试应用CsA改善原因不明流产者的妊娠结局[3]。这些均提示CsA对妊娠有保护作用。鉴于此，本文就目前CsA调节妊娠的相关分子机制的研究进展进行综述。

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