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卵巢上皮性癌组织中TLR4/MyD88信号通路的表达及其与临床预后的关系
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- Author:
- No author available
- Journal Title:
- Chinese Journal of Obstetrics and Gynecology
- Issue:
- 9
- DOI:
- 10.3760/cma.j.issn.0529-567x.2013.09.015
- Key Word:
- No keyword available
Abstract： 卵巢上皮性癌(卵巢癌)是病死率最高的妇科恶性肿瘤,手术加以紫杉醇为基础的联合化疗仍然是卵巢癌主要的治疗方法,但80％以上的患者最终将因肿瘤复发或转移导致病情恶化[1].化疗耐药制约着卵巢癌患者的长期生存,而紫杉醇耐药是卵巢癌复发的主要原因[2-3].近来的研究显示,紫杉醇耐药可能与卵巢癌细胞表面Toll样受体4(Toll-like receptor,TLR4)、髓样细胞分化因子88(myeloid differentiation factor 88,MyD88)的表达及TLR4/MyD88信号传导关系密切[3-6].但卵巢癌TLR4/MyD88的表达水平、其在肿瘤生物学方面的作用以及对临床预后的影响尚无大样本量的临床证据.本研究旨在探讨卵巢癌TLR4/MyD88信号通路的表达及其与临床预后的相关性,从而进一步了解TLR4、MyD88与卵巢癌发生、发展、侵袭、转移及预后的相互关系,并为深入阐明卵巢癌的发病机制和避免或逆转TLR4/MyD88信号通路介导的紫杉醇耐药提供新的化疗策略.
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