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组蛋白去乙酰化酶抑制剂apicidin对子宫内膜癌细胞凋亡及HDAC4和p21表达的影响
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- Author:
- No author available
- Journal Title:
- Chinese Journal of Obstetrics and Gynecology
- Issue:
- 3
- DOI:
- 10.3760/cma.j.issn.0529-567x.2013.03.014
- Key Word:
- No keyword available
Abstract： 子宫内膜癌是女性生殖器官三大恶性肿瘤之一,占女性生殖道恶性肿瘤的20％ ～ 30％,近年来在世界范围内发病率呈上升趋势[1].表观遗传学改变是恶性肿瘤发生的主要机制之一,组蛋白去乙酰化是表观遗传学改变的一种[2].研究发现,通过组蛋白去乙酰化酶抑制剂(histone deacetylase inhibitor,HDACi)作用于子宫内膜癌细胞,可以上调抑癌基因p21的表达而使肿瘤细胞的活性受到抑制[3],还能引起细胞周期的阻断和肿瘤细胞选择性凋亡,具有潜在的抗肿瘤作用[4].本研究通过HDACi-apicidin作用于不同类型的子宫内膜癌细胞,探讨apicidin对子宫内膜癌发生、发展的作用机制.
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