Pregnancy outcomes of patients with polycystic ovary syndrome undergoing in vitro fertilization and embryo transfer
- Author:
- No author available
- Journal Title:
- Chinese Journal of Obstetrics and Gynecology
- Issue:
- 12
- DOI:
- 10.3760/cma.j.issn.0529-567x.2011.12.010
- Key Word:
- 多囊卵巢综合征;受精,体外;胚胎移植;妊娠结局;Polycystic ovary syndrome;Fertilization in vitro;Embryo transfer;Pregnancyoutcome
Abstract： Objectives To study pregnant outcomes of patients with polycystic ovary syndrome (PCOS) undergoing in vitro fertilization and embryo transfer (IVF-ET),and analyze the differences of pregnant outcomes in patients with various phenotypes of PCOS.Methods From Jan.2005 to Feb.2010,631 PCOS patients (PCOS group)and 1423 patients with tubal infertility (control group) who underwent IVF-ET with matched age and body mass index were selected in Center for Reproductive Medicine of the Provincial Hospital Affiliated to Shandong University.Retrospective study was carried out,and pregnancy outcomes were compared between two groups.Results The rates of abortion and preterm birth in PCOS group were significantly higher than those in control group [22.7％ ( 143/631 ) vs.18.69％ (266/1423) and 11.2％ (38/339) vs.6.4％ (51/794) respectively,all P ＜0.05 ].The rates of gestational diabetes mellitus were 1.5％ (5/339) in PCOS and 0.6％ (5/794) in control group,respectively; the rates of pregnancy induced hypertension syndrome were 4.7％ (16/339) in PCOS and 3.0％ (24/794) in control group; gestational days were(272 ± 13) days in PCOS and(273 ± l0)days in control group; the rates of neonatal deformity were 0.6％ (2/339) in PCOS and O.8％ (6/794) in control group; weight of newborn infants in the two groups was(3.5 ±0.5 ) kg; and there was no significant difference between two groups in the above index ( all P ＞ O.05 ).Ovulatory PCOS patients had similar abortion rate [ 18.6％ (19/102) ] and preterm birth rate [ 8.2％ (4/49) ] when compared with those of control group (P ＞ 0.05 ).Conversely,oligo-ovulatory PCOS patients showed higher abortion rate [ 23.4％ ( 124/529 ) ] and preterm birth rate [ 11.7％ (34/290) ] than those of control group ( P ＜ 0.05 ).Conclusions PCOS patients after IVF-ET have an increased abortion rate and preterm birth rate.However,ovulatory PCOS did not present various pregnancy complications.Non-polycystic ovary PCOS patients have worse pregnancy outcome.Ovarian dysfunction might be related to obstetric complications.
- [1]CHEN Zi-jiang,SHI Yu-hua,李媛,等.多囊卵巢综合征不孕患者辅助生殖治疗临床效果分析[J].2008,(8).
- [2]张二红,梁晓燕,杜静,等.多囊卵巢综合征无排卵患者子宫内膜超声形态学及组织学变化[J].2006,(6).
- [3]Macklon NS,Boomsma CM,Fauser BC.Pregnancy complications in women with polycystic ovary syndrome.[J].2008,26(1).
- [4]Fauser BC,Eijkemans MJ,de Valk HW,etc.Sex hormone-binding globulin concentrations before conception as a predictor for gestational diabetes in women with polycystic ovary syndrome.[J].2010,25(12).
- [5]H, Watson,D S, Kiddy,D, Hamilton-Fairley,etc.Hypersecretion of luteinizing hormone and ovarian steroids in women with recurrent early miscarriage.[J].1993,8.
- [6]Angela, Falbo,Morena, Rocca,Tiziana, Russo,etc.Changes in androgens and insulin sensitivity indexes throughout pregnancy in women with polycystic ovary syndrome (PCOS): relationships with adverse outcomes.[J].2010,3.
- [7]Williams MA,Qiu C,Lohsoonthorn V.Maternal serum C-reactive protein concentrations in early pregnancy and subsequent risk of preterm delivery.[J].2007,40(5).
- [8]Russo T,Palomba S,Zullo F,etc.Pregnancy in women with polycystic ovary syndrome: the effect of different phenotypes and features on obstetric and neonatal outcomes.[J].2010,94(5).
- [9].Characteristics of different phenotypes of polycystic ovary syndrome based on the Rotterdam criteria in a large-scale Chinese population.[J].2009,116(12).
- [10]Maija Tulppala,Ulf-Håkan Stenman,Bruno Cacciatore,etc.Polycystic ovaries and levels of gonadotrophins and androgens in recurrent miscarriage: prospective study in 50 women[J].1993,100(4).
- [11]Homburg R.Pregnancy complications in PCOS.[J].2006,20(2).
- [12]von Eye Corleta H,Strowitzki T,Capp E.The degree of cycle irregularity correlates with the grade of endocrine and metabolic disorders in PCOS patients.[J].2010,149(2).
- [13]Visser GH,Fauser BC,Boomsma CM,etc.A meta-analysis of pregnancy outcomes in women with polycystic ovary syndrome.[J].2006,12(6).
- [14]Russo T,Battista L,Palomba S,etc.Uterine blood flow in pregnant patients with polycystic ovary syndrome: relationships with clinical outcomes.[J].2010,117(6).
- [15]Radon PA,McMahon MJ,Meyer WR.Impaired glucose tolerance in pregnant women with polycystic ovary syndrome.[J].1999,94(2).
- [16]Gao X,Shi Y,Zhang P,etc.Clinical and metabolic characteristics of polycystic ovary syndrome without polycystic ovary: a pilot study on Chinese women.[J].2008,90(4).
- [17]Goulis DG,Kolibianakis EM,Toulis KA.Risk of gestational diabetes mellitus in women with polycystic ovary syndrome: a systematic review and a meta-analysis.[J].2009,92(2).
- [18]Altieri P,Gambineri A,Pasquali R,etc.Maternal polycystic ovary syndrome may be associated with adverse pregnancy outcomes.[J].2010,149(1).