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人乳头状瘤病毒16型E6基因的小分子干扰RNA对子宫颈癌细胞生长的影响
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- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF OBSTETRICS AND GYNECOLOGY
- Issue:
- 2
- DOI:
- 10.3760/j.issn:0529-567X.2007.02.018
- Key Word:
- No keyword available
Abstract： @@ 宫颈癌是一种常见的妇科恶性肿瘤.研究发现,人乳头状瘤病毒(HPV)是本病发生的一个重要病毒性致癌因子.大约80%的宫颈癌可检测到HPV16,其E6基因是致癌的关键基因,绝大多数宫颈癌HPV16、18 E6癌蛋白通过泛素依赖的途径与p53蛋白结合,导致p53蛋白降解,致使细胞无限增殖[1].
- [1]牛晓宇,彭芝兰,王和.RNA干涉抑制宫颈癌 CaSki细胞株 HPV16 E6基因的研究[J].2004,(11).
- [2]Xian He, Xie,Hee Jung, An,Suki, Kang,etc.Loss of Cyclin B1 followed by downregulation of Cyclin A/Cdk2, apoptosis and antiproliferation in Hela cell line.[J].2005,116.
- [3]Butz K,Hoppe Seyler F,Denk C,etc.siRNA targeting of the viral E6 oncogene efficiently kills human papillomavirus-positive cancer cells.[J].2003,22(38).
- [4]Jiang M,Milner J.Selective silencing of viral gene expression in HPV-positive human cervical carcinoma cells treated with siRNA, a primer of RNA interference.[J].2002,21(39).
- [5]Thomas M,Banks L,Pim D.The role of the E6-p53 interaction in the molecular pathogenesis of HPV.[J].1999,18(53).
- [6]P D, Zamore,T, Tuschl,P A, Sharp,etc.RNAi: double-stranded RNA directs the ATP-dependent cleavage of mRNA at 21 to 23 nucleotide intervals.[J].2000,101(1).