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Temporal and spatial expression of estrogen activity-related molecules in eutopic endometrium of adenomyosis
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- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF OBSTETRICS AND GYNECOLOGY
- Issue:
- 4
- DOI:
- 10.3760/j.issn:0529-567X.2004.04.009
- Key Word:
- 子宫肿瘤;腺肌瘤;子宫内膜;受体,雌激素;17-羟甾类脱氢酶类
Abstract： 目的探讨子宫腺肌症(腺肌症)患者在位子宫内膜、内膜-肌层界面(endometrial-myometrial interface, EMI)处,雌激素效应相关因子的时空表达及其对腺肌症发病的影响.方法收集正常妇女子宫内膜(及部分肌层)33例(正常内膜组)和腺肌症患者在位内膜(及部分肌层)18例(腺肌症组),采用免疫组化方法测定、分析雌激素效应相关因子--雌激素受体α(ERα)、雌激素受体β(ERβ)、17β羟类固醇脱氢酶Ⅰ(17β-HSDⅠ)和17β羟类固醇脱氢酶Ⅱ(17β-HSDⅡ)的时空变化.结果 (1)腺肌症组ERα阳性的腺上皮细胞数量在增殖早期为90 %,正常内膜组为60%;且腺上皮细胞胞质中也可见到ERα阳性颗粒.(2)腺肌症组在位内膜腺上皮细胞在增殖早期、晚期和分泌晚期,17β-HSDⅠ阳性信号强度分别为(++)、(+++)和(++),较正常内膜组相应时期的(+)、(++)和(+)有所增高;腺肌症组在位内膜腺上皮细胞在增殖早期和分泌期,17β-HSDⅡ阳性信号强度分别为(+++)和(++++),较正常内膜组相应时期的(-～++)和(+++)有一定增高.(3)腺肌症组EMI上ERα、ERβ和17β-HSDⅠ阳性信号强度显著增强,而17β-HSDⅡ者降低.结论腺肌症患者子宫内膜中ERα阳性细胞数量增加、17β-HSDⅠ普遍高强度、17β-HSDⅡ代偿性增加不足,以及EMI方向性生长位点ERα、ERβ、17β-HSDⅠ和17β-HSDⅡ表达强度的变化,会导致局部雌激素效应增强、增殖活性增强.
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