You Position: Home > Paper
子宫颈癌组织中热休克蛋白90α mRNA表达的研究
( views:173, downloads:24 )
- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF OBSTETRICS AND GYNECOLOGY
- Issue:
- 2
- DOI:
- 10.3760/j.issn:0529-567X.2004.02.017
- Key Word:
- No keyword available
Abstract： @@ 近年来,对热休克蛋白90(heat shock protein 90,HSP90)基因的生物学作用研究发现,其表达量的变化与肿瘤的发生关系密切.其中,HSP90α基因在不同病理分化程度的肿瘤组织和肿瘤细胞中呈选择性高表达[1].我们也曾经观察到HSP90基因在两株克隆形成率不同的子宫颈癌亚克隆细胞株中的表达有明显差异[2].为了探明HSP90α基因在人子宫颈癌发生、发展中的作用,我们用RT-PCR方法检测宫颈癌组织中HSP90α mRNA的表达.现将结果报道如下.
- [1]乔绘红,赵玫,袁兴华.热休克蛋白90α的表达及其对体内肿瘤生长的影响[J].1999,(1).
- [2]Pratt WB..The hsp90-based chaperone system: Involvement in signal transduction from a variety of hormone and growth factor receptors [Review][J].1998,217(4).
- [3]M, Yano,Z, Naito,S, Tanaka,etc.Expression and roles of heat shock proteins in human breast cancer.[J].1996,87.
- [4]Liu J,DeFranco DB.Chromatin recycling of glucocorticoid receptors: implications for multiple roles of heat shock protein 90.[J].1999,13(3).
- [5]H J, Ochel,T W, Schulte,P, Nguyen,etc.The benzoquinone ansamycin geldanamycin stimulates proteolytic degradation of focal adhesion kinase.[J].1999,66(1).
- [6]Chadli A,Bouhouche I,Kang KI,etc.The molecular chaperone Hsp90 can negatively regulate the activity of a glucocorticosteroid-dependent promoter.[J].1999,96(4).
- [7]T M, Gress,F, Müller-Pillasch,C, Weber,etc.Differential expression of heat shock proteins in pancreatic carcinoma.[J].1994,54.
- [8]内藤善哉,乔炎,浅野伍朗.热休克蛋白在人乳腺癌中的作用[J].1998,(1).