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Application of synthetic biology in bladder cancer

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Author:: No author available

Journal Title:: Chinese Medical Journal

Issue:: 18

DOI:: 10.1097/CM9.0000000000002344

Key Word:: Bladder cancer;Synthetic biology;Gene circuits;T cell immunotherapy;Nanomaterials;Bladder cancer;Synthetic biology;Gene circuits;T cell immunotherapy;Nanomaterials

Abstract： Bladder cancer (BC) is the most common malignant tumor of the genitourinary system. The age of individuals diagnosed with BC tends to decrease in recent years. A variety of standard therapeutic options are available for the clinical management of BC, but limitations exist. It is difficult to surgically eliminate small lesions, while radiation and chemotherapy damage normal tissues, leading to severe side effects. Therefore, new approaches are required to improve the efficacy and specificity of BC treatment. Synthetic biology is a field emerging in the last decade that refers to biological elements, devices, and materials that are artificially synthesized according to users’ needs. In this review, we discuss how to utilize genetic elements to regulate BC-related gene expression periodically and quantitatively to inhibit the initiation and progression of BC. In addition, the design and construction of gene circuits to distinguish cancer cells from normal cells to kill the former but spare the latter are elaborated. Then, we introduce the development of genetically modified T cells for targeted attacks on BC. Finally, synthetic nanomaterials specializing in detecting and killing BC cells are detailed. This review aims to describe the innovative details of the clinical diagnosis and treatment of BC from the perspective of synthetic biology.

Reference

[1]Kuzmin, Dmitry A.,Shutova, Maria V.,Johnston, Natalie R.,etc.The clinical landscape for AAV gene therapies[J].2021,20(3).
[2]Zah, Eugenia,Lin, Meng-Yin,Silva-Benedict, Anne,etc.T Cells Expressing CD19/CD20 Bispecific Chimeric Antigen Receptors Prevent Antigen Escape by Malignant B Cells[J].2016,4(6).
[3]Fan, Lin,Liang, Dong,Weiming, Wang,etc.An Efficient Light-Inducible P53 Expression System for Inhibiting Proliferation of Bladder Cancer Cell.[J].2016,(10).
[4]Xu Yadong,Luo Cheng,Wang Jieqiong,etc.Application of nanotechnology in the diagnosis and treatment of bladder cancer[J].2021,19(1).
[5]MacKay Matthew,Afshinnekoo Ebrahim,Rub Jonathan,etc.The therapeutic landscape for cells engineered with chimeric antigen receptors[J].2020,38(2).
[6]Zhang, Pu,Zhang, Yanning,Liu, Wenhao,etc.A Molecular Beacon Based Surface-Enhanced Raman Scattering Nanotag for Noninvasive Diagnosis of Bladder Cancer[J].2019,15(7).
[7]Liu, Yuchen,Zeng, Yayue,Liu, Li,etc.Synthesizing AND gate genetic circuits based on CRISPR-Cas9 for identification of bladder cancer cells[J].2014,5(Nov.).
[8]Wu, Ming-Ru,Jusiak, Barbara,Lu, Timothy K..Engineering advanced cancer therapies with synthetic biology[J].2019,19(4).
[9]Liu Li,Liu Yuchen,Zhang Tianbiao,etc.Synthetic Bax-Anti Bcl2 combination module actuated by super artificial hTERT promoter selectively inhibits malignant phenotypes of bladder cancer[J].2016,35(1).
[10]Haiying,Qin,Sneha,Ramakrishna,Sang,Nguyen,etc.Preclinical Development of Bivalent Chimeric Antigen Receptors Targeting Both CD19 and CD22.[J].2018,11.
[11]Jianye,Liu,Yi,Zhang,Qinghai,Zeng,etc.Delivery of RIPK4 small interfering RNA for bladder cancer therapy using natural halloysite nanotubes.[J].2019,5(9).
[12]Guangzhi,Li,Qifang,Lei,Fei,Wang,etc.Fluorinated Polymer Mediated Transmucosal Peptide Delivery for Intravesical Instillation Therapy of Bladder Cancer.[J].2019,15(25).
[13]Yoon, Ho Yub,Yang, Hee Mang,Kim, Chang Hyun,etc.Current status of the development of intravesical drug-delivery systems for the treatment of bladder cancer[J].2020,17(7/12).
[14]Horstmann M,Pesch B,Johnen G,etc.Clinical experience with survivin as a biomarker for urothelial bladder cancer.[J].2010,28(3).
[15]Li, Guangzhi,Wang, Shupeng,Deng, Dashi,etc.Fluorinated Chitosan To Enhance Transmucosal Delivery of Sonosensitizer- Conjugated Catalase for Sonodynamic Bladder Cancer Treatment Post-intravesical Instillation[J].2020,14(2).
[16]Sun, Rui,Liu, Xiaocen,Li, Guangzhi,etc.Photoactivated H-2 Nanogenerator for Enhanced Chemotherapy of Bladder Cancer[J].2020,14(7).
[17].CRISPR/Cas Derivatives as Novel Gene Modulating Tools: Possibilities and In Vivo Applications[J].2020,21(8).
[18]Zhan, Hengji,Xie, Haibiao,Zhou, Qun,etc.Synthesizing a Genetic Sensor Based on CRISPR-Cas9 for Specifically Killing p53-Deficient Cancer Cells[J].2018,7(7).
[19]Bueso, Yensi Flores,Lehouritis, Panos,Tangney, Mark.In situ biomolecule production by bacteria; a synthetic biology approach to medicine[J].2018,275.
[20]Pausch, Patrick,Al-Shayeb, Basem,Bisom-Rapp, Ezra,etc.CRISPR-CasΦ from huge phages is a hypercompact genome editor[J].2020,369(Jul.17 TN.6501).
[21]Yuchen, Liu,Jianfa, Li,Zhicong, Chen,etc.Synthesizing artificial devices that redirect cellular information at will.[J].2018,7(Spec ).
[22]Liu Yuchen,Huang Weiren,Cai Zhiming.Synthesizing AND gate minigene circuits based on CRISPReader for identification of bladder cancer cells[J].2020,11(1).
[23]Xu, Lei,Wang, Jun,Liu, Yulin,etc.CRISPR-Edited Stem Cells in a Patient with HIV and Acute Lymphocytic Leukemia[J].2019,381(13).
[24]Liu Yuchen,Zhan Yonghao,Chen Zhicong,etc.Directing cellular information flow via CRISPR signal conductors[J].2016,13(11).
[25]Kiani, Samira,Chavez, Alejandro,Tuttle, Marcelle,etc.Cas9 gRNA engineering for genome editing, activation and repression[J].2015,12(11).
[26]Hakim,Manghwar,Keith,Lindsey,Xianlong,Zhang,etc.CRISPR/Cas System: Recent Advances and Future Prospects for Genome Editing.[J].2019,24(12).
[27]Hengji,Zhan,Qun,Zhou,Qunjun,Gao,etc.Multiplexed promoterless gene expression with CRISPReader.[J].2019,20(1).
[28]Simon MA,Koya MP,Soloway MS.Complications of intravesical therapy for urothelial cancer of the bladder.[J].2006,175(6).
[29]McNerney Monica P.,Doiron Kailyn E.,Ng Tai L.,etc.Theranostic cells: emerging clinical applications of synthetic biology[J].2021,22(11).
[30]Fang, Diana,Maldonado, Eduardo N..VDAC Regulation: A Mitochondrial Target to Stop Cell Proliferation[J].2018,138.
[31]Tiffany Chien,Anjali Doshi,Tal Danino.Advances in bacterial cancer therapies using synthetic biology[J].2017,5.
[32]Truong, Dong-Jiunn Jeffery,Kuehner, Karin,Kuehn, Ralf,etc.Development of an intein-mediated split-Cas9 system for gene therapy[J].2015,43(13).
[33]Hortelao, Ana C.,Carrascosa, Rafael,Murillo-Cremaes, Nerea,etc.Targeting 3D Bladder Cancer Spheroids with Urease-Powered Nanomotors[J].2019,13(1).
[34]Tran, Linda,Xiao, Jin-Fen,Agarwal, Neeraj,etc.Advances in bladder cancer biology and therapy[J].2021,21(2).
[35]Simson, Paivo,Jepihhina, Natalja,Laasmaa, Martin,etc.Restricted ADP movement in cardiomyocytes: Cytosolic diffusion obstacles are complemented with a small number of open mitochondrial voltage-dependent anion channels[J].2016,97.
[36].Alterations of Antioxidant Enzymes and Biomarkers of Nitro-oxidative Stress in Tissues of Bladder Cancer[J].2019.
[37]Zhu, Pengli,Huang, Cheng,Hu, Tingting,etc.Mammalian drug efflux transporters of the ATP binding cassette (ABC) family in multidrug resistance: A review of the past decade[J].2016,370(1).
[38]Kinde,I.,Munari,E.,Faraj,S.F.,etc.TERT promoter mutations occur early in urothelial neoplasia and are biomarkers of early disease and disease recurrence in urine[J].2013,73(24).
[39]Alban, Luisa,Monteiro, Wesley Formentin,Diz, Fernando Mendonca,etc.New quercetin-coated titanate nanotubes and their radiosensitization effect on human bladder cancer[J].2020,110.
[40]Zhicong, Chen,Yuchen, Liu,Anbang, He,etc.Theophylline controllable RNAi-based genetic switches regulate expression of lncRNA TINCR and malignant phenotypes in bladder cancer cells.[J].2016.
[41]Yang, Yang,Wang, Lili,Bell, Peter,etc.A dual AAV system enables the Cas9-mediated correction of a metabolic liver disease in newborn mice[J].2016,34(3).
[42].Poly(amidoamine)-modified mesoporous silica nanoparticles as a mucoadhesive drug delivery system for potential bladder cancer therapy[J].2020,189.
[43]Vormittag, Philipp,Gunn, Rebecca,Ghorashian, Sara,etc.A guide to manufacturing CAR T cell therapies[J].2018,53.
[44]Yuchen, Liu,Jinghong, Han,Zhicong, Chen,etc.Engineering cell signaling using tunable CRISPR-Cpf1-based transcription factors.[J].2017,8(1).
[45]Ryosuke Kojima,Martin Fussenegger.Synthetic Biology: Engineering Mammalian Cells To Control Cell‐to‐Cell Communication at Will[J].2019,20(8).
[46]Tao, Kepeng,Liu, Shuwei,Wang, Lu,etc.Targeted multifunctional nanomaterials with MRI, chemotherapy and photothermal therapy for the diagnosis and treatment of bladder cancer[J].2020,8(1).
[47]Xiong Qiao,Liu Anwei,Ren Qian,etc.Cuprous oxide nanoparticles trigger reactive oxygen species-induced apoptosis through activation of erk-dependent autophagy in bladder cancer[J].2020,11(5).
[48]Robert W, Robey,Kristen M, Pluchino,Matthew D, Hall,etc.Revisiting the role of ABC transporters in multidrug-resistant cancer.[J].2018,(Spec ).
[49]Zah Eugenia,Nam Eunwoo,Bhuvan Vinya,etc.Systematically optimized BCMA/CS1 bispecific CAR-T cells robustly control heterogeneous multiple myeloma[J].2020,11(1).
[50]Lasic, Eva,Visnjar, Tanja,Kreft, Mateja Erdani.Properties of the Urothelium that Establish the Blood-Urine Barrier and Their Implications for Drug Delivery[J].2015,168.
[51]Tao,Wu,Xi,Duan,Chunyan,Hu,etc.Synthesis and characterization of gold nanoparticles from Abies spectabilis extract and its anticancer activity on bladder cancer T24 cells.[J].2019,47(1).
[52]Xu, Xin,Liu, Kunpeng,Jiao, Binbin,etc.Mucoadhesive nanoparticles based on ROS activated gambogic acid prodrug for safe and efficient intravesical instillation chemotherapy of bladder cancer[J].2020,324.
[53]Xie, Mingqi,Fussenegger, Martin.Designing cell function: assembly of synthetic gene circuits for cell biology applications[J].2018,19(8).
[54]Larson, Rebecca C.,Maus, Marcela V..Recent advances and discoveries in the mechanisms and functions of CAR T cells[J].2021,21(3).
[55]Cho, Suehyun K.,Su, Lih-Jen,Mao, Chenchen,etc.Multifunctional nanoclusters of NaYF4:Yb3+,Er3+ upconversion nanoparticle and gold nanorod for simultaneous imaging and targeted chemotherapy of bladder cancer[J].2019,97.
[56]Taylor D,Scott,Kieran,Sweeney,Megan N,McClean.Biological signal generators: integrating synthetic biology tools and in silico control.[J].2019,14.