Abstract： To the Editor:Malassezia and Staphylococcus epidermidis (S.epidermidis) are commensal organisms found on human skin,and both display an imbalance of colonization in individuals with seborrheic dermatitis/dandruff (SD/D).[1-3]Malassezia have been implicated in SD/D pathogenesis,as evidenced by an imbalance in the numbers of Malassezia that colonize the skin lesions of people with SD/D,and the fact that antifungal treatment exerts a modifying effect.[4] Among Malassezia species,Malassezia furfur (M.furfur) is the predominant in Chinese seborrheic dermatitis (SD) patients.[5] Recently,large numbers of S.epidermidis have been found in the lesions of individuals with acquired immunodeficiency syndrome (AIDS)-related SD,classical SD,and dandruff.[1,2] A topical antibiotic cream such as fusidic acid cream can often improve the symptoms of SD,suggesting a pathological role for S.epidermidis in SD.[1] Whether co-colonization of Malassezia and S.epidermidis in the skin lesions of SD/D suggests their biological interactions is an interesting topic to investigate.