Efficacy of weight adjusted bone mineral content in osteoporosis diagnosis in Chinese female population
- Author:
- No author available
- Journal Title:
- Chinese Medical Journal
- Issue:
- 7
- DOI:
- 10.1097/CM9.0000000000000143
- Key Word:
- Bone mineral content;Weight-standardized bone mineral content;Bone density;Dual-energy X-ray absorptiometry;Osteoporosis
Abstract： Background:Areal bone mineral density (aBMD) applied for osteoporosis diagnosis unavoidably results in the missingdiagnosis in patients with large bones and misdiagnosis in those with small bones.Therefore,we try to find a new adjusted index of bone mineral content (BMC) to make up shortcomings of aBMD in osteoporosis diagnosis.Methods:In this multi-center epidemiological study,BMC and aBMD of lumbar spines (n =5510) and proximal femurs (n =4710) were measured with dual energy X-ray absorptiometry (DXA).We analyzed the correlation between the bone mass and body weight in all subjects including four age groups (＜19 years,20-39 years,40-49 years,＞50 years).And then the body weight was used for standardizing BMC (named wBMC) and applied for the epidemiologica[analysis of osteoporosis.Results:The correlation of body weight and BMC is 0.839 to 0.931 of lumbar vertebra 1-4 (L1-4),and 0.71 to 0.95 of femoral neck in different age groups.When aBMD was applied for diagnosing osteoporosis,the prevalence was 7.55 ％,16.39％,and 25.83 ％ in patients with a high,intermediate,and low body weight respectively.However,the prevalence was 21.8 ％,18.03 ％,and 11.64 ％ by wBMC applied for diagnosing osteoporosis.Moreover,the prevalence of osteoporosis increased by 3.76 ％ by wBMC with the body weight increased by 5 kg.The prevalence decreased by 1.94％ when the body weight decreased by 5 kg.Conclusions:wBMC can reduce the missed diagnosis in patients with large body weight and reduce misdiagnosis in those with small body weight.Including children,wBMC may be feasible for osteoporosis diagnosis individuals at any age.
- [1]刘加昌,张瑾,欧阳巧洪,等.北京城区10~12岁女孩骨密度的研究[J].2002,(2).
- [2]D R, Carter,M L, Bouxsein,R, Marcus.New approaches for interpreting projected bone densitometry data.[J].1992,7.
- [3]Huang QR,Koh LK,Rajatanavin R,etc.A simple tool to identify asian women at increased risk of osteoporosis.[J].2001,12(8).
- [4]Khadilkar VV,Khadilkar AV,Chiplonkar SA,etc.Determinants of bone mineral content and bone area in Indian preschool children.[J].2011,29(3).
- [5]H. Rico,M. Revilla,L.F. Villa,etc.Determinants of total-body and regional bone mineral content and density in postpubertal normal women[J].1994,43(2).
- [6]Compston J. E.,Laskey M. A.,Croucher P. I.,etc.Effect of diet-induced weight loss on total body bone mass[J].1992.
- [7]Parfitt Am,Duan Y,Seeman E.Vertebral bone mass, size, and volumetric density in women with spinal fractures.[J].1999,14(10).
- [8]LLoyd Jones SA,Howman Giles R,Briody JN,etc.Volumetric bone mineral density in normal subjects, aged 5-27 years.[J].1996,81(4).
- [9]Ling, Oei,Fjorda, Koromani,Fernando, Rivadeneira,etc.Quantitative imaging methods in osteoporosis.[J].2016,(6).
- [10]Kanis, J. A.,Melton, L. J.,Christiansen, C.,etc.Perspective: The Diagnosis of Osteoporosis[J].1994,9(8).
- [11]Roberto, Bernabei,Anna Maria, Martone,Elena, Ortolani,etc.Screening, diagnosis and treatment of osteoporosis: a brief review.[J].2014,11(3).
- [12]H M, Frost.A determinant of bone architecture. The minimum effective strain.[J].1983,(175).
- [13]Salvioli G,Bedogni G,Malavolti M,etc.Relationship between body composition and bone mineral content in young and elderly women.[J].2002,29(5).
- [14]Liu JL,Yang DZ,Cheng XG,etc.Age-related bone mineral density, bone loss rate, prevalence of osteoporosis, and reference database of women at multiple centers in China.[J].2007,10(3).
- [15]H.M. Frost.Defining osteopenias and osteoporoses: Another view (with insights from a new paradigm)[J].1997,20(5).
- [16]徐健,杨定焯,马锦富,等.骨力学负荷对峰值骨量的影响及骨量标准化方法探索[J].2010,(7).