Paper - WANFANG MED ONLINE

You Position: Home > Paper

Ovarian Fibrosis: A Phenomenon of Concern

( views:47, downloads:24 )

Author:: No author available

Journal Title:: Chinese Medical Journal

Issue:: 3

DOI:: 10.4103/0366-6999.198931

Key Word:: Cytokine;Fibrosis;Ovarian Chocolate Cyst;Polycystic Ovarian Syndrome;Premature Ovarian Failure

Abstract： Objective:Ovarian fibrosis is characterized by excessive proliferation of ovarian fibroblasts and deposition of extracellular matrix (ECM)and it is one of the principal reasons for ovarian dysfunction.This review aimed to investigate the pathogenetic mechanism of ovarian fibrosis and to clarify the relationship between ovarian diseases and fibrosis.Data Sources:We searched PubMed for English language articles published up to November 2016.The search terms included ovarian fibrosis OR fibrosis,ovarian chocolate cyst OR ovarian endometrioma,polycystic ovarian syndrome (PCOS),premature ovarian failure,ECM,matrix metalloproteinases (MMPs),tissue inhibitors of matrix metalloproteinases (TIMPs),transforming growth factor-beta 1 (TGF-β 1),connective tissue growth factor (CTGF),peroxisome proliferator-activated receptor gamma (PPAR-γ),vascular endothelial growth factor (VEGF),endothelin-1 (ET-1),and combinations of these terms.Study Selection:Articles were obtained and reviewed to analyze the pathogenic mechanism of ovarian fibrosis and related ovarian diseases.Results:Many cytokines,such as MMPs,TIMPs,TGF-β1,CTGF,PPAR-γ,VEGF,and ET-1,are involved in ovarian fibrogenesis.Ovarian fibrogenesis is associated with various ovarian diseases,including ovarian chocolate cyst,PCOS,and premature ovarian failure.One finding of particular interest is that fibrogenesis in peripheral tissues around an ovarian chocolate cyst commonly causes ovarian function diminution,and therefore,this medical problem should arouse widespread concem in clinicians worldwide.Conclusions:Patients with ovarian fibrosis are susceptible to infertility and tend to have decreased responses to assisted fertility treatment.Thus,protection of ovarian function should be a priority for women who wish to reproduce when making therapeutic decisions about ovarian fibrosis-related diseases.

Reference

[1]MIAO Zhu Lin,GUO Liang,WANG Yong Xia,etc.The Intervention Effect of Rosiglitozone in Ovarian Fibrosis of PCOS Rats[J].2012,(1).
[2]Jian-bo LAI,Chun-Fang Qiu,Chuan-Xi Chen,etc.Inhibition of c-Jun N-terminal Kinase Signaling Pathway Alleviates Lipopolysaccharide-induced Acute Respiratory Distress Syndrome in Rats[J].2016,(14).
[3]Cui Yang,Si-Dao Zheng,Hong-jin Wu,etc.Regulatory Mechanisms of the Molecular Pathways in Fibrosis Induced by MicroRNAs[J].2016,(19).
[4]Zhang, Qi,Duan, Jie,Liu, Xishi,etc.Platelets drive smooth muscle metaplasia and fibrogenesis in endometriosis through epithelial-mesenchymal transition and fibroblast-to-myofibroblast transdifferentiation[J].2016,428(C).
[5]Schubert B,Matsuzaki S.Oxidative stress status in normal ovarian cortex surrounding ovarian endometriosis.[J].2010,93(7).
[6]J, Donnez,M, Nisolle,N, Gillet,etc.Large ovarian endometriomas.[J].1996,11.
[7]Boss EA,Massuger LF,van Schaik JH,etc.Clinical value of components of the plasminogen activation system in ovarian cyst fluid.[J].2002,22(1A).
[8]Belo VA,Gomes VA,Soares GM,etc.Imbalanced circulating matrix metalloproteinases in polycystic ovary syndrome.[J].2011,353(1).
[9]Reza, Asadzadeh,Shima, Khosravi,Saeed, Zavareh,etc.Vitrification affects the expression of matrix metalloproteinases and their tissue inhibitors of mouse ovarian tissue.[J].2016.
[10]Kenneth E, Lipson,Carol, Wong,Yuchin, Teng,etc.CTGF is a central mediator of tissue remodeling and fibrosis and its inhibition can reverse the process of fibrosis.[J].2012,5(Suppl 1).
[11]Laura Proud Smith,Christopher D. Williams,Joseph O.’Brien Doyle,etc.Effect of endometrioma cyst fluid exposure on peritoneal adhesion formation in a rabbit model[J].2007,87(5).
[12]Wang,L.,Ying,Y.-F.,Ouyang,Y.-L.,etc.VEGF and bFGF increase survival of xenografted human ovarian tissue in an experimental rabbit model[J].2013,30(10).
[13]Benoît Schubert,Michel Canis,Claude Darcha,etc.Human ovarian tissue from cortex surrounding benign cysts: a model to study ovarian tissue cryopreservation.[J].2005,20(7).
[14]Zhang,X.,Zhang,C.,Shen,S.,etc.Dehydroepiandrosterone induces ovarian and uterine hyperfibrosis in female rats[J].2013,28(11).
[15]Yuhui Yang,Alexr V. Bazhin,Jens Werner,etc.Reactive Oxygen Species in the Immune System[J].2013,32(1).
[16]Apostolopoulos,N.V.,Jude,E.B.,Watson,A.J.,etc.Effects of low-dose metformin and rosiglitazone on biochemical, clinical, metabolic and biophysical outcomes in polycystic ovary syndrome[J].2013,33(2).
[17]Maria P, Alfaro,Desirae L, Deskins,Meredith, Wallus,etc.A physiological role for connective tissue growth factor in early wound healing.[J].2013,93.
[18]P E, HUGHESDON.The structure of endometrial cysts of the ovary.[J].1957,64(4).
[19]Benaglia,L.,Bermejo,A.,Somigliana,E.,etc.In vitro fertilization outcome in women with unoperated bilateral endometriomas[J].2013,99(6).
[20]Gulay, Bulut,Zehra, Kurdoglu,Yeliz Bozdemir, D?nmez,etc.Effects of jnk inhibitor on inflammation and fibrosis in the ovary tissue of a rat model of polycystic ovary syndrome.[J].2015,8(8).
[21]Velasco I,Acien P,Ruiz Macia E,etc.Interleukin-6 and other soluble factors in peritoneal fluid and endometriomas and their relation to pain and aromatase expression.[J].2010,84(2).
[22]Rossi, A. Cristina,Prefumo, Federico.The effects of surgery for endometriosis on pregnancy outcomes following in vitro fertilization and embryo transfer: a systematic review and meta-analysis[J].2016,294(3).
[23]Shirly Lahav-Baratz,Zaki Kraiem,Hanna Shiloh,etc.Decreased expression of tissue inhibitor of matrix metalloproteinases in follicular fluid from women with polycystic ovaries compared with normally ovulating patients undergoing in vitro fertilization[J].2003,79(3).
[24].Fell-Muir lecture: Connective tissue growth factor (CCN2) - a pernicious and pleiotropic player in the development of kidney fibrosis[J].2013,94(1).
[25]Jie Yang,Ting Zhong,Guohong Xiao,etc.Polymorphisms and haplotypes of the TGF-β1 gene are associated with risk of polycystic ovary syndrome in Chinese Han women[J].2015,186.
[26]Oytun Erbas,Halil Gursoy Pala,Emel Ebru Pala,etc.Ovarian failure in diabetic rat model: Nuclear factor-kappaB, oxidative stress, and pentraxin-3[J].2014,53(4).
[27]Irving Rodgers HF,Rodgers RJ.Extracellular matrix of the developing ovarian follicle.[J].2006,24(4).
[28]Dolmans MM,Kitajima M,Colette S,etc.Endometriomas as a possible cause of reduced ovarian reserve in women with endometriosis.[J].2011,96(3).
[29]Dumesic, Daniel A.,Meldrum, David R.,Katz-Jaffe, Mandy G.,etc.Oocyte environment: follicular fluid and cumulus cells are critical for oocyte health[J].2015,103(2).
[30]Qiuju Chen,Xiaoxi Sun,Junling Chen,etc.Direct rosiglitazone action on steroidogenesis and proinflammatory factor production in human granulosa-lutein cells[J].2009,7(1).
[31]Yucel Karaman,Husamettin Uslu.Complications and their management in endometriosis surgery.[J].2015,11(5).
[32]St?mpfli,M.R.,Foster,W.G.,Gannon,A.M..Cigarette smoke exposure elicits increased autophagy and dysregulation of mitochondrial dynamics in murine granulosa cells[J].2013,88(3).
[33]Nicholas, Bryan,Helen, Ahswin,Neil, Smart,etc.Reactive oxygen species (ROS)--a family of fate deciding molecules pivotal in constructive inflammation and wound healing.[J].2012,24.
[34]Szmidt, Natasha A. K.,Bhattacharya, Siladitya,Maheshwari, Abha.Does poor ovarian response to gonadotrophins predict early menopause? A retrospective cohort study with minimum of 10-year follow-up[J].2016,19(1).
[35]Yang,C.,Kang,L.,Zhang,X.,etc.Differential expression of CTGF in pre- and post-ovulatory granulosa cells in the hen ovary is regulated by TGFβ1 and gonadotrophins[J].2012,178(2).
[36]Piomboni,P.,Focarelli,R.,Capaldo,A.,etc.Protein modification as oxidative stress marker in follicular fluid from women with polycystic ovary syndrome: the effect of inositol and metformin[J].2014,31(10).
[37]Christopher R, Harlow,Lindsay, Davidson,Kathleen H, Burns,etc.FSH and TGF-beta superfamily members regulate granulosa cell connective tissue growth factor gene expression in vitro and in vivo.[J].2002,143.
[38]Erbas, Oytun,Pala, Halil Gursoy,Pala, Emel Ebru,etc.Therapeutic effect of sunitinib on diabetes mellitus related ovarian injury: an experimental rat model study[J].2015,31(5).
[39]Hart, Roger J..Physiological Aspects of Female Fertility: Role of the Environment, Modern Lifestyle, and Genetics[J].2016,96(3).
[40]Liu B,Zheng JH,Guan YM.Elevated serum levels of matrix metalloproteinase-2 in women with polycystic ovarian syndrome.[J].2007,96(3).
[41]Shilpa, Prasad,Meenakshi, Tiwari,Ashutosh N, Pandey,etc.Impact of stress on oocyte quality and reproductive outcome.[J].2016.
[42]Ola, Hadadeh,Emilie, Barruet,Franck, Peiretti,etc.The plasminogen activation system modulates differently adipogenesis and myogenesis of embryonic stem cells.[J].2012,7(11).
[43]Wang,Y.-X.,Zhu,W.-J.,Xie,B.-G..Expression of PPAR-γ in adipose tissue of rats with polycystic ovary syndrome induced by DHEA[J].2014,9(3).
[44]Luciana F, Rom?o,Fabio A, Mendes,Natalia M, Feitosa,etc.Connective tissue growth factor (CTGF/CCN2) is negatively regulated during neuron-glioblastoma interaction.[J].2013,8(1).
[45]Peter J, Wermuth,Zhaodong, Li,Fabian A, Mendoza,etc.Stimulation of Transforming Growth Factor-β1-Induced Endothelial-To-Mesenchymal Transition and Tissue Fibrosis by Endothelin-1 (ET-1): A Novel Profibrotic Effect of ET-1.[J].2016.
[46]Stephan Gordts,Patrick Puttemans,Sylvie Gordts,etc.Ovarian endometrioma in the adolescent: a plea for early-stage diagnosis and full surgical treatment[J].2015,12(1).
[47]K NB,Chakravarty B,Jana SK,etc.Upper control limit of reactive oxygen species in follicular fluid beyond which viable embryo formation is not favorable.[J].2010,29(4).
[48]Liu Z,Zhao M,Chang C,etc.The level of vascular endothelial cell growth factor, nitric oxide, and endothelin-1 was correlated with ovarian volume or antral follicle counts: a potential predictor of pregnancy outcome in IVF.[J].2010,28(5).
[49]Park CM,Rhee CH,Park IC,etc.Transforming growth factor-beta1 induces tissue inhibitor of metalloproteinase-1 expression via activation of extracellular signal-regulated kinase and Sp1 in human fibrosarcoma cells.[J].2006,4(3).
[50]Barnes JL,Gorin Y.Myofibroblast differentiation during fibrosis: role of NAD(P)H oxidases.[J].2011,79(9).
[51]Samarakoon, R.,Overstreet, J.M.,Higgins, P.J..TGF-β signaling in tissue fibrosis: Redox controls, target genes and therapeutic opportunities (Review)[J].2013,25(1).